The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

BET proteins commonly activate cellular gene expression, yet inhibiting their recruitment paradoxically reactivates latent HIV-1 transcription. Here we identify the short isoform of BET family member BRD4 (BRD4S) as a corepressor of HIV-1 transcription. We found that BRD4S was enriched in chromatin...

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Veröffentlicht in:	Molecular cell 2017-09, Vol.67 (6), p.1001-1012.e6
Hauptverfasser:	Conrad, Ryan J., Fozouni, Parinaz, Thomas, Sean, Sy, Hendrik, Zhang, Qiang, Zhou, Ming-Ming, Ott, Melanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Azepines - pharmacology BET protein BRD4 BRG1 bromodomain chromatin Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly - drug effects Chromatin Immunoprecipitation Chromosomal Proteins, Non-Histone - drug effects Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism DNA Helicases - genetics DNA Helicases - metabolism DNA, Viral - genetics DNA, Viral - metabolism Dose-Response Relationship, Drug Down-Regulation gene expression Gene Expression Regulation, Viral genomics HEK293 Cells High-Throughput Nucleotide Sequencing HIV HIV-1 - drug effects HIV-1 - genetics HIV-1 - immunology HIV-1 - metabolism Host-Pathogen Interactions Human immunodeficiency virus 1 Humans JQ1 Jurkat Cells latency LTR Nuclear Proteins - genetics Nuclear Proteins - metabolism nucleosomes precipitin tests Promoter Regions, Genetic Protein Binding Protein Isoforms protein subunits Retroelements retrotransposons RNA Interference SWI/SNF T-lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - virology terminal repeat sequences Time Factors transcription (genetics) Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - drug effects Transfection Triazoles - pharmacology Virus Latency - drug effects
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