Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas

Isolated limb perfusion (ILP) with the chemotherapeutic agent melphalan is an effective treatment option for extremity in-transit melanoma but is toxic and technically challenging to deliver locoregionally. CBL0137 is an experimental clinical drug with broad anticancer activity in animal models, owi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-11, Vol.76 (22), p.6620-6630
Hauptverfasser:	Kim, Minhyung, Neznanov, Nickolay, Wilfong, Chandler D, Fleyshman, Daria I, Purmal, Andrei A, Haderski, Gary, Stanhope-Baker, Patricia, Burkhart, Catherine A, Gurova, Katerina V, Gudkov, Andrei V, Skitzki, Joseph J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Extremities - pathology Female Humans Infusion Pumps Melanoma - drug therapy Melanoma - pathology Mice Mice, Inbred C57BL Treatment Outcome Validation Studies as Topic
Online-Zugang:	Volltext
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