DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

Plasmodium vivax is the most prevalent parasite species that causes malaria in humans and exclusively infects reticulocytes. Reticulocyte infection is facilitated by P vivax Duffy binding protein (DBP), which utilizes DARC (Duffy antigen receptor for chemokines) as an entry point. However, the selec...

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Veröffentlicht in:	Blood 2017-09, Vol.130 (12), p.1441-1444
Hauptverfasser:	Ovchynnikova, Elina, Aglialoro, Francesca, Bentlage, Arthur E.H., Vidarsson, Gestur, Salinas, Nichole D., von Lindern, Marieke, Tolia, Niraj H., van den Akker, Emile
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Specificity - immunology Antigens, Protozoan - metabolism Brief Report Cell Differentiation Duffy Blood-Group System - chemistry Duffy Blood-Group System - metabolism Erythrocytes - parasitology Extracellular Space - chemistry Humans Plasmodium vivax - physiology Protein Domains Protozoan Proteins - metabolism Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Red Cells, Iron, and Erythropoiesis Reticulocytes - cytology Reticulocytes - metabolism Structure-Activity Relationship Tropism - physiology
Online-Zugang:	Volltext
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