Triptolide inhibits the function of TNF-α in osteoblast differentiation by inhibiting the NF-κB signaling pathway

Chronic inflammation often delays fracture healing or leads to bone nonunion. Effectively suppressing pathological inflammation is crucial for fracture healing or bone remodeling. Triptolide, which is a diterpenoid epoxide, is the major active component of the Thunder God Vine, Tripterygium wilfordi...

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Veröffentlicht in:	Experimental and therapeutic medicine 2017-09, Vol.14 (3), p.2235-2240
Hauptverfasser:	Liu, Shen-Peng, Wang, Guo-Dong, Du, Xue-Jun, Wan, Guang, Wu, Jun-Tao, Miao, Lian-Bao, Liang, Qiu-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	bone morphogenetic protein-1 Cytokines fracture healing Gene expression Inflammation Kinases osteoblast differentiation Physiology Proteins Rheumatoid arthritis Stem cells Studies triptolide Tumor necrosis factor-TNF
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