Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P‑Glycoprotein in the Blood–Brain Barrier

P-glycoprotein is an efflux transporter located in the blood–brain barrier. (R)-[11C]Verapamil is widely used as a PET tracer to investigate its function in patients with epilepsy, Alzheimer’s disease, and other neurodegenerative diseases. Currently it is not possible to use this successful tracer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ACS chemical neuroscience 2017-09, Vol.8 (9), p.1925-1936
Hauptverfasser:	Raaphorst, Renske M, Luurtsema, Gert, Schuit, Robert C, Kooijman, Esther J. M, Elsinga, Philip H, Lammertsma, Adriaan A, Windhorst, Albert D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B - deficiency ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - deficiency ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP-Binding Cassette Sub-Family B Member 4 Blood-Brain Barrier - metabolism Central Nervous System Agents - pharmacology Drug Evaluation, Preclinical Drug Stability Male Mice, Knockout Molecular Structure Positron-Emission Tomography Quinolines - pharmacology Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Rats, Wistar Tissue Distribution Verapamil - chemical synthesis Verapamil - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!