Crystal structure of the UBR‐box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding

The UBR‐box is a 70‐residue zinc finger domain present in the UBR family of E3 ubiquitin ligases that directly binds N‐terminal degradation signals in substrate proteins. UBR6, also called FBXO11, is an UBR‐box containing E3 ubiquitin ligase that does not bind N‐terminal signals. Here, we present th...

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Veröffentlicht in:	Protein science 2017-10, Vol.26 (10), p.2092-2097
Hauptverfasser:	Muñoz‐Escobar, Juliana, Kozlov, Guennadi, Gehring, Kalle
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Binding Crystal structure Crystallography, X-Ray domain swapping F-Box Proteins - chemistry F-Box Proteins - metabolism Histidine Humans Models, Molecular Protein Binding Protein Domains Protein Structure Reports Protein-Arginine N-Methyltransferases - chemistry Protein-Arginine N-Methyltransferases - metabolism Proteins Topology Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases UBR‐box domain X‐ray crystallography Zinc Zinc - chemistry Zinc - metabolism Zinc coordination zinc finger Zinc finger proteins Zinc Fingers
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