Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways

Polydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms in in vitro and in vivo models. IgE-mediated passive cutaneous anaphylaxis (PCA) and passive systemic anaphylaxis (PSA) models were used to confirm PD effect in vivo . Various signaling pathw...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.11895-13, Article 11895
Hauptverfasser:	Ye, Jing, Piao, Hongmei, Jiang, Jingzhi, Jin, Guangyu, Zheng, Mingyu, Yang, Jinshi, Jin, Xiang, Sun, Tianyi, Choi, Yun Ho, Li, Liangchang, Yan, Guanghai
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 38/77 38/90 631/250 631/337 64/60 AKT protein Anaphylaxis Anaphylaxis - drug therapy Anaphylaxis - immunology Anaphylaxis - pathology Animal models Animals Cell Degranulation - drug effects Cell Degranulation - immunology Cytokines - immunology Cytotoxicity Degranulation Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Enzyme-linked immunosorbent assay Extracellular Signal-Regulated MAP Kinases - immunology Fyn protein Glucosides - pharmacology Heme Oxygenase-1 - immunology Histamine Humanities and Social Sciences Hypersensitivity Immunoglobulin E Inflammation - drug therapy Inflammation - immunology Inflammation - pathology Inflammatory diseases Interleukin 4 Interleukin 8 Kinases Male MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Mast cells Mast Cells - immunology Mast Cells - pathology Membrane Proteins - immunology Mice Mice, Inbred BALB C multidisciplinary NF-E2-Related Factor 2 - immunology NF-κB protein Passive cutaneous anaphylaxis Phosphatidylinositol 3-Kinases - immunology Pigmentation Polymerase chain reaction Proto-Oncogene Proteins c-akt - immunology Science Science (multidisciplinary) Signal transduction Stilbenes - pharmacology Syk protein Tumor necrosis factor-α Western blotting
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