Type I IFNs and TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation

Cross-regulation of Toll-like receptor responses by cytokines is essential for effective host defense, avoidance of toxicity, and homeostasis, but the underlying mechanisms are not well understood. A comprehensive epigenomic approach in human macrophages showed that the proinflammatory cytokines TNF...

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Veröffentlicht in:	Nature immunology 2017-08, Vol.18 (10), p.1104-1116
Hauptverfasser:	Park, Sung Ho, Kang, Kyuho, Giannopoulou, Eugenia, Qiao, Yu, Kang, Keunsoo, Kim, Geonho, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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