ADAM10-mediated ICOSL Shedding on B cells is Necessary for Proper T cell ICOS Regulation and TFH Responses

The proper regulation of inducible costimulator (ICOS) and its ligand (ICOSL) have been shown to be essential for maintaining proper immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant antibody production resembling lupus....

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Veröffentlicht in:	The Journal of immunology (1950) 2017-08, Vol.199 (7), p.2305-2315
Hauptverfasser:	Lownik, Joseph C, Luker, Andrea J., Damle, Sheela R., Cooley, Lauren Folgosa, El Sayed, Riham, Hutloff, Andreas, Pitzalis, Costantino, Martin, Rebecca K., El Shikh, Mohey Eldin M, Conrad, Daniel H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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