Prognostic Significance of Host-related Biomarkers for Survival in Patients with Advanced Non-Small Cell Lung Cancer
This study identified host-related prognostic biomarkers for survival in patients with advanced non-small cell lung cancer (NSCLC). This study was based on the retrospective review of the medical records of 135 patients with pathologically confirmed advanced NSCLC. The host-related biomarkers assess...
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| Veröffentlicht in: | Journal of Cancer 2017-01, Vol.8 (15), p.2974-2983 |
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| creator | Lee, Sookyung Eo, Wankyu Jeon, Hyeonjin Park, Sora Chae, Jean |
| description | This study identified host-related prognostic biomarkers for survival in patients with advanced non-small cell lung cancer (NSCLC).
This study was based on the retrospective review of the medical records of 135 patients with pathologically confirmed advanced NSCLC. The host-related biomarkers assessed in this study that reflected patient condition included hemoglobin (Hb) levels; platelet (PLT), neutrophil, lymphocyte, and monocyte counts; and ferritin concentrations. The overall survival (OS) was calculated by Kaplan-Meier analysis and compared using log-rank tests. Univariate and multivariate analyses of Cox proportional hazards regression were used to evaluate the prognostic impact for survival.
Of the enrolled patients, 91.1% had stage IV NSCLC, 42.2% had ECOG-PS scores of 2, and 57% had undergone multiple rounds of prior systemic therapy. The prognostic factors included low Hb concentration (men: Hb < 13 g/dL, women: Hb < 12 g/dL;
0.046), increased neutrophil count (> 7,700 cells/μL;
< 0.001), decreased lymphocyte count (≤ 1500 cells/μL;
= 0.011), increased monocyte count (> 800 cells/μL;
0.001), and high ferritin level (men: > 200 ng/mL, women: > 150 ng/mL;
0.001), which were associated with poor OS and increased hazard of mortality. The multivariate proportional hazards model revealed that lymphocyte count, monocyte count, and ferritin level were independent host-related prognostic biomarkers for survival. Increased monocyte count (HR, 3.15; 95% CI, 1.64-6.04;
0.001) and high ferritin level (HR, 1.81; 95% CI, 1.24-2.64;
0.002) were significantly associated with poor survival, whereas increased lymphocyte count (HR, 0.57; 95% CI, 0.40-0.83;
0.004) showed prolonged survival.
Immune factors, such as lymphocyte and monocyte counts, as well as serum ferritin levels, are significant host-related prognostic biomarkers for survival with direct relevance to survival time in patients with advanced NSCLC. |
| doi_str_mv | 10.7150/jca.20866 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5604449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1941102898</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-b52874aef89467a3b070b78ad47883962962bb213bf8cd540f070d4a48c732c33</originalsourceid><addsrcrecordid>eNpVkdFOwyAUhonRuGXuwhcwXOpFJy200BuTuagzWXTJ9JpQSjdmBxPaGd9e5uYyyQmccL78nMMPwGWMBjRO0e1SikGCWJadgG7MMI3yLCOnR3kH9L1forBwnlCCz0EnYXnCGMu7oJk6OzfWN1rCmZ4bXWkpjFTQVnAcriOnatGoEt5ruxLuQzkPK-vgrHUbvRE11AZORaOVaTz80s0CDsvNVqCEL9ZEs5WoazhSYZu0Zg5H25K7AGeVqL3q788eeH98eBuNo8nr0_NoOIkkpmkTFWnCKBGqYjnJqMAFoqigTJSEMobzLAlRFEmMi4rJMiWoCkBJBGGS4kRi3AN3O911W6xUKUOTTtR87XQY5Ztbofn_itELPrcbnmaIEJIHgeu9gLOfrfINX2kvwzTCKNt6HuckjlH4TRbQmx0qnfXeqerwTIz41igejOK_RgX26rivA_lnC_4B6i2Phg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1941102898</pqid></control><display><type>article</type><title>Prognostic Significance of Host-related Biomarkers for Survival in Patients with Advanced Non-Small Cell Lung Cancer</title><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Lee, Sookyung ; Eo, Wankyu ; Jeon, Hyeonjin ; Park, Sora ; Chae, Jean</creator><creatorcontrib>Lee, Sookyung ; Eo, Wankyu ; Jeon, Hyeonjin ; Park, Sora ; Chae, Jean</creatorcontrib><description>This study identified host-related prognostic biomarkers for survival in patients with advanced non-small cell lung cancer (NSCLC).
This study was based on the retrospective review of the medical records of 135 patients with pathologically confirmed advanced NSCLC. The host-related biomarkers assessed in this study that reflected patient condition included hemoglobin (Hb) levels; platelet (PLT), neutrophil, lymphocyte, and monocyte counts; and ferritin concentrations. The overall survival (OS) was calculated by Kaplan-Meier analysis and compared using log-rank tests. Univariate and multivariate analyses of Cox proportional hazards regression were used to evaluate the prognostic impact for survival.
Of the enrolled patients, 91.1% had stage IV NSCLC, 42.2% had ECOG-PS scores of 2, and 57% had undergone multiple rounds of prior systemic therapy. The prognostic factors included low Hb concentration (men: Hb < 13 g/dL, women: Hb < 12 g/dL;
0.046), increased neutrophil count (> 7,700 cells/μL;
< 0.001), decreased lymphocyte count (≤ 1500 cells/μL;
= 0.011), increased monocyte count (> 800 cells/μL;
0.001), and high ferritin level (men: > 200 ng/mL, women: > 150 ng/mL;
0.001), which were associated with poor OS and increased hazard of mortality. The multivariate proportional hazards model revealed that lymphocyte count, monocyte count, and ferritin level were independent host-related prognostic biomarkers for survival. Increased monocyte count (HR, 3.15; 95% CI, 1.64-6.04;
0.001) and high ferritin level (HR, 1.81; 95% CI, 1.24-2.64;
0.002) were significantly associated with poor survival, whereas increased lymphocyte count (HR, 0.57; 95% CI, 0.40-0.83;
0.004) showed prolonged survival.
Immune factors, such as lymphocyte and monocyte counts, as well as serum ferritin levels, are significant host-related prognostic biomarkers for survival with direct relevance to survival time in patients with advanced NSCLC.</description><identifier>ISSN: 1837-9664</identifier><identifier>EISSN: 1837-9664</identifier><identifier>DOI: 10.7150/jca.20866</identifier><identifier>PMID: 28928889</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher</publisher><subject>Research Paper</subject><ispartof>Journal of Cancer, 2017-01, Vol.8 (15), p.2974-2983</ispartof><rights>Ivyspring International Publisher 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-b52874aef89467a3b070b78ad47883962962bb213bf8cd540f070d4a48c732c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604449/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604449/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28928889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sookyung</creatorcontrib><creatorcontrib>Eo, Wankyu</creatorcontrib><creatorcontrib>Jeon, Hyeonjin</creatorcontrib><creatorcontrib>Park, Sora</creatorcontrib><creatorcontrib>Chae, Jean</creatorcontrib><title>Prognostic Significance of Host-related Biomarkers for Survival in Patients with Advanced Non-Small Cell Lung Cancer</title><title>Journal of Cancer</title><addtitle>J Cancer</addtitle><description>This study identified host-related prognostic biomarkers for survival in patients with advanced non-small cell lung cancer (NSCLC).
This study was based on the retrospective review of the medical records of 135 patients with pathologically confirmed advanced NSCLC. The host-related biomarkers assessed in this study that reflected patient condition included hemoglobin (Hb) levels; platelet (PLT), neutrophil, lymphocyte, and monocyte counts; and ferritin concentrations. The overall survival (OS) was calculated by Kaplan-Meier analysis and compared using log-rank tests. Univariate and multivariate analyses of Cox proportional hazards regression were used to evaluate the prognostic impact for survival.
Of the enrolled patients, 91.1% had stage IV NSCLC, 42.2% had ECOG-PS scores of 2, and 57% had undergone multiple rounds of prior systemic therapy. The prognostic factors included low Hb concentration (men: Hb < 13 g/dL, women: Hb < 12 g/dL;
0.046), increased neutrophil count (> 7,700 cells/μL;
< 0.001), decreased lymphocyte count (≤ 1500 cells/μL;
= 0.011), increased monocyte count (> 800 cells/μL;
0.001), and high ferritin level (men: > 200 ng/mL, women: > 150 ng/mL;
0.001), which were associated with poor OS and increased hazard of mortality. The multivariate proportional hazards model revealed that lymphocyte count, monocyte count, and ferritin level were independent host-related prognostic biomarkers for survival. Increased monocyte count (HR, 3.15; 95% CI, 1.64-6.04;
0.001) and high ferritin level (HR, 1.81; 95% CI, 1.24-2.64;
0.002) were significantly associated with poor survival, whereas increased lymphocyte count (HR, 0.57; 95% CI, 0.40-0.83;
0.004) showed prolonged survival.
Immune factors, such as lymphocyte and monocyte counts, as well as serum ferritin levels, are significant host-related prognostic biomarkers for survival with direct relevance to survival time in patients with advanced NSCLC.</description><subject>Research Paper</subject><issn>1837-9664</issn><issn>1837-9664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkdFOwyAUhonRuGXuwhcwXOpFJy200BuTuagzWXTJ9JpQSjdmBxPaGd9e5uYyyQmccL78nMMPwGWMBjRO0e1SikGCWJadgG7MMI3yLCOnR3kH9L1forBwnlCCz0EnYXnCGMu7oJk6OzfWN1rCmZ4bXWkpjFTQVnAcriOnatGoEt5ruxLuQzkPK-vgrHUbvRE11AZORaOVaTz80s0CDsvNVqCEL9ZEs5WoazhSYZu0Zg5H25K7AGeVqL3q788eeH98eBuNo8nr0_NoOIkkpmkTFWnCKBGqYjnJqMAFoqigTJSEMobzLAlRFEmMi4rJMiWoCkBJBGGS4kRi3AN3O911W6xUKUOTTtR87XQY5Ztbofn_itELPrcbnmaIEJIHgeu9gLOfrfINX2kvwzTCKNt6HuckjlH4TRbQmx0qnfXeqerwTIz41igejOK_RgX26rivA_lnC_4B6i2Phg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Lee, Sookyung</creator><creator>Eo, Wankyu</creator><creator>Jeon, Hyeonjin</creator><creator>Park, Sora</creator><creator>Chae, Jean</creator><general>Ivyspring International Publisher</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Prognostic Significance of Host-related Biomarkers for Survival in Patients with Advanced Non-Small Cell Lung Cancer</title><author>Lee, Sookyung ; Eo, Wankyu ; Jeon, Hyeonjin ; Park, Sora ; Chae, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-b52874aef89467a3b070b78ad47883962962bb213bf8cd540f070d4a48c732c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sookyung</creatorcontrib><creatorcontrib>Eo, Wankyu</creatorcontrib><creatorcontrib>Jeon, Hyeonjin</creatorcontrib><creatorcontrib>Park, Sora</creatorcontrib><creatorcontrib>Chae, Jean</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sookyung</au><au>Eo, Wankyu</au><au>Jeon, Hyeonjin</au><au>Park, Sora</au><au>Chae, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Host-related Biomarkers for Survival in Patients with Advanced Non-Small Cell Lung Cancer</atitle><jtitle>Journal of Cancer</jtitle><addtitle>J Cancer</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>8</volume><issue>15</issue><spage>2974</spage><epage>2983</epage><pages>2974-2983</pages><issn>1837-9664</issn><eissn>1837-9664</eissn><abstract>This study identified host-related prognostic biomarkers for survival in patients with advanced non-small cell lung cancer (NSCLC).
This study was based on the retrospective review of the medical records of 135 patients with pathologically confirmed advanced NSCLC. The host-related biomarkers assessed in this study that reflected patient condition included hemoglobin (Hb) levels; platelet (PLT), neutrophil, lymphocyte, and monocyte counts; and ferritin concentrations. The overall survival (OS) was calculated by Kaplan-Meier analysis and compared using log-rank tests. Univariate and multivariate analyses of Cox proportional hazards regression were used to evaluate the prognostic impact for survival.
Of the enrolled patients, 91.1% had stage IV NSCLC, 42.2% had ECOG-PS scores of 2, and 57% had undergone multiple rounds of prior systemic therapy. The prognostic factors included low Hb concentration (men: Hb < 13 g/dL, women: Hb < 12 g/dL;
0.046), increased neutrophil count (> 7,700 cells/μL;
< 0.001), decreased lymphocyte count (≤ 1500 cells/μL;
= 0.011), increased monocyte count (> 800 cells/μL;
0.001), and high ferritin level (men: > 200 ng/mL, women: > 150 ng/mL;
0.001), which were associated with poor OS and increased hazard of mortality. The multivariate proportional hazards model revealed that lymphocyte count, monocyte count, and ferritin level were independent host-related prognostic biomarkers for survival. Increased monocyte count (HR, 3.15; 95% CI, 1.64-6.04;
0.001) and high ferritin level (HR, 1.81; 95% CI, 1.24-2.64;
0.002) were significantly associated with poor survival, whereas increased lymphocyte count (HR, 0.57; 95% CI, 0.40-0.83;
0.004) showed prolonged survival.
Immune factors, such as lymphocyte and monocyte counts, as well as serum ferritin levels, are significant host-related prognostic biomarkers for survival with direct relevance to survival time in patients with advanced NSCLC.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher</pub><pmid>28928889</pmid><doi>10.7150/jca.20866</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| title | Prognostic Significance of Host-related Biomarkers for Survival in Patients with Advanced Non-Small Cell Lung Cancer |
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