Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

Despite a clear correlation between periodontitis and cognitive decline in Alzheimer’s disease, the precise mechanism underlying the relationship remains unclear. The periodontal pathogen Porphyromonas gingivalis produces a unique class of cysteine proteinases termed gingipains that comprises Arg-gi...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.11759-13, Article 11759
Hauptverfasser:	Liu, Yicong, Wu, Zhou, Nakanishi, Yurika, Ni, Junjun, Hayashi, Yoshinori, Takayama, Fumiko, Zhou, Yanmin, Kadowaki, Tomoko, Nakanishi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/21 13/51 13/95 14 14/19 631/378/2596/1953 631/80/84/1372 AKT protein Cell adhesion & migration Cell migration Cognitive ability Extracellular signal-regulated kinase Gingipain Humanities and Social Sciences Inflammation Intracellular signalling Kinases MAP kinase Metabolic pathways Microglia multidisciplinary Par-2 protein Periodontitis Porphyromonas gingivalis Protein kinase Science Science (multidisciplinary)
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