Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma

We hypothesized that clonidine and propranolol would increase VEGF and VEGF-receptor expression and promote lung healing following severe trauma and chronic stress. Sprague-Dawley rats were subjected to lung contusion (LC), lung contusion/hemorrhagic shock (LCHS), or lung contusion/hemorrhagic shock...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of surgery 2017-10, Vol.214 (4), p.610-615
Hauptverfasser:	Loftus, Tyler J., Thomson, Andrew J., Kannan, Kolenkode B., Alamo, Ines G., Millar, Jessica K., Plazas, Jessica M., Whitley, Elizabeth E., Efron, Philip A., Mohr, Alicia M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Catheters Clonidine Clonidine - pharmacology Healing Hemorrhage HMGB1 protein HMGB1 Protein - metabolism Infiltration Inflammation Inflammation - drug therapy Light microscopy Lung contusion Lung Injury - drug therapy Lungs Propranolol Propranolol - pharmacology Pulmonary Edema - drug therapy Rats Rats, Sprague-Dawley Repair Restraint, Physical Rodents Stress Stress response Surgery Tissue engineering Tissue repair Tissues Trauma Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors Wound healing Wound Healing - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We hypothesized that clonidine and propranolol would increase VEGF and VEGF-receptor expression and promote lung healing following severe trauma and chronic stress. Sprague-Dawley rats were subjected to lung contusion (LC), lung contusion/hemorrhagic shock (LCHS), or lung contusion/hemorrhagic shock/daily restraint stress (LCHS/CS). Clonidine and propranolol were administered daily. On day seven, lung VEGF, VEGFR-1, VEGFR-2, and HMGB1 were assessed by PCR. Lung injury was assessed by light microscopy (*p
ISSN:	0002-9610 1879-1883
DOI:	10.1016/j.amjsurg.2017.06.019