Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant–anticoagulant equilibrium toward thrombosis

Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active α-thrombin (αT). In the prothrombinase complex on the platelet surface, FXa cleaves ProT at Arg-271, generating the inactive precursor pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2017-09, Vol.292 (37), p.15161-15179
Hauptverfasser:	Pontarollo, Giulia, Acquasaliente, Laura, Peterle, Daniele, Frasson, Roberta, Artusi, Ilaria, De Filippis, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bacillus subtilis - enzymology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Blood Coagulation - drug effects Catalytic Domain coagulation factor Editors' Picks Enzyme Activation - drug effects Enzyme Stability - drug effects Female Humans infection Male Models, Molecular Peptide Fragments - agonists Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Platelet Aggregation - drug effects Protein Conformation Protein Interaction Domains and Motifs proteolysis Proteolysis - drug effects prothrombin Prothrombin - agonists Prothrombin - chemistry Prothrombin - genetics Prothrombin - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism serine protease Serine Proteinase Inhibitors - pharmacology Substrate Specificity Subtilisin - antagonists & inhibitors Subtilisin - metabolism Thrombosis - etiology Thrombosis - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!