Haplotype of the Interleukin 17A gene is associated with osteitis after Bacillus Calmette-Guerin vaccination

Bacillus Calmette-Guerin (BCG) osteitis was more common in Finland than elsewhere at the time when universal BCG vaccinations were given to Finnish newborns. There is evidence that IL-17 plays a role in the defense against tuberculosis. The aim of this study was to evaluate the associations of IL17A...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.11691-5, Article 11691
Hauptverfasser:	Korppi, Matti, Teräsjärvi, Johanna, Liehu-Martiskainen, Milla, Lauhkonen, Eero, Vuononvirta, Juho, Nuolivirta, Kirsi, Kröger, Liisa, Pöyhönen, Laura, Karjalainen, Minna K., He, Qiushui
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/77 692/308/2056 692/308/3187 Alleles Bacillus Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - administration & dosage BCG Vaccine - adverse effects Finland Gene frequency Genetic Predisposition to Disease Haplotypes Humanities and Social Sciences Humans Immunization Interleukin 1 Interleukin 17 Interleukin-17 - genetics multidisciplinary Mycobacterium bovis - immunology Neonates Osteitis Osteitis - genetics Polymorphism Polymorphism, Single Nucleotide Science Science (multidisciplinary) Single-nucleotide polymorphism Tuberculosis Vaccination
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