Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility

The Arp2/3 complex nucleates branched actin, forming networks involved in lamellipodial protrusion, phagocytosis, and cell adhesion. We derived primary bone marrow macrophages lacking Arp2/3 complex (Arpc2−/−) and directly tested its role in macrophage functions. Despite protrusion and actin assembl...

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Veröffentlicht in:	Developmental cell 2017-09, Vol.42 (5), p.498-513.e6
Hauptverfasser:	Rotty, Jeremy D., Brighton, Hailey E., Craig, Stephanie L., Asokan, Sreeja B., Cheng, Ning, Ting, Jenny P., Bear, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actin-Related Protein 2-3 Complex - metabolism Actins - metabolism Animals Arp2/3 Cell Movement - drug effects Cell Shape - drug effects Chemokine CX3CL1 - pharmacology Chemotaxis - drug effects Colony-Stimulating Factors - pharmacology directed migration Female Fibronectins - pharmacology integrin Integrins - metabolism Ligands macrophage Macrophage-1 Antigen - metabolism Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Macrophages - ultrastructure Male Mice, Inbred C57BL Myosin Heavy Chains - metabolism phagocytosis Phagocytosis - drug effects Phenotype Receptors, Fc - metabolism Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects
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