T2-relaxation time increases in lumbar intervertebral discs after 21d head-down tilt bed-rest

Spaceflight back pain and intervertebral disc (IVD) herniations cause problems in astronauts. Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. 8 men participated in the bed-rest study. Subjects...

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Veröffentlicht in:	Journal of musculoskeletal & neuronal interactions 2017-09, Vol.17 (3), p.140-145
Hauptverfasser:	Koy, T, Ganse, B, Zange, J, Rittweger, J, Pohle-Fröhlich, R, Fings-Meuthen, P, Johannes, B, Felsenberg, D, Eysel, P, Bansmann, P M, Belavý, D L
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Sprache:	eng
Schlagworte:	Bed Rest Bicarbonates - pharmacology Cross-Over Studies Dietary Supplements Head-Down Tilt Humans Intervertebral Disc - drug effects Intervertebral Disc - physiopathology Low Back Pain - etiology Low Back Pain - physiopathology Lumbar Vertebrae Magnetic Resonance Imaging Male Original Potassium Compounds - pharmacology Space Flight Weightlessness Simulation
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creator	Koy, T Ganse, B Zange, J Rittweger, J Pohle-Fröhlich, R Fings-Meuthen, P Johannes, B Felsenberg, D Eysel, P Bansmann, P M Belavý, D L
description	Spaceflight back pain and intervertebral disc (IVD) herniations cause problems in astronauts. Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. 8 men participated in the bed-rest study. Subjects remained in 6° head down tilt bed-rest in two campaigns of 21 days, and received a nutritional intervention (potassium bicarbonate 90 mmol/d) in a cross-over design. MRI measurements were performed 2 days before bed-rest, as well as one and five days after getting up. Image segmentation and data analysis were conducted for the IVDs Th12/L1 to L5/S1. 7 subjects, average age of 27.6 (SD 3.3) years, completed the study. Results showed a significant increase in T2-time in all IVDs (p⟨0.001), more pronounced in the nucleus pulposus than in the annulus fibrosus (p⟨0.001). Oral potassium bicarbonate did not show an effect (p=0.443). Pfirrmann-grade correlated with the T2-time (p⟨0.001). 6° head-down tilt bed-rest leads to a T2-time increase in lumbar IVDs. Oral potassium bicarbonate supplementation does not have an effect on IVD T2-time.
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Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. 8 men participated in the bed-rest study. Subjects remained in 6° head down tilt bed-rest in two campaigns of 21 days, and received a nutritional intervention (potassium bicarbonate 90 mmol/d) in a cross-over design. MRI measurements were performed 2 days before bed-rest, as well as one and five days after getting up. Image segmentation and data analysis were conducted for the IVDs Th12/L1 to L5/S1. 7 subjects, average age of 27.6 (SD 3.3) years, completed the study. Results showed a significant increase in T2-time in all IVDs (p⟨0.001), more pronounced in the nucleus pulposus than in the annulus fibrosus (p⟨0.001). Oral potassium bicarbonate did not show an effect (p=0.443). Pfirrmann-grade correlated with the T2-time (p⟨0.001). 6° head-down tilt bed-rest leads to a T2-time increase in lumbar IVDs. 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Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. 8 men participated in the bed-rest study. Subjects remained in 6° head down tilt bed-rest in two campaigns of 21 days, and received a nutritional intervention (potassium bicarbonate 90 mmol/d) in a cross-over design. MRI measurements were performed 2 days before bed-rest, as well as one and five days after getting up. Image segmentation and data analysis were conducted for the IVDs Th12/L1 to L5/S1. 7 subjects, average age of 27.6 (SD 3.3) years, completed the study. Results showed a significant increase in T2-time in all IVDs (p⟨0.001), more pronounced in the nucleus pulposus than in the annulus fibrosus (p⟨0.001). Oral potassium bicarbonate did not show an effect (p=0.443). Pfirrmann-grade correlated with the T2-time (p⟨0.001). 6° head-down tilt bed-rest leads to a T2-time increase in lumbar IVDs. 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subjects	Bed Rest Bicarbonates - pharmacology Cross-Over Studies Dietary Supplements Head-Down Tilt Humans Intervertebral Disc - drug effects Intervertebral Disc - physiopathology Low Back Pain - etiology Low Back Pain - physiopathology Lumbar Vertebrae Magnetic Resonance Imaging Male Original Potassium Compounds - pharmacology Space Flight Weightlessness Simulation
title	T2-relaxation time increases in lumbar intervertebral discs after 21d head-down tilt bed-rest
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