Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

Wound healing is one of the most complex biological processes to occur in life. Repair of tissue following injury involves dynamic interactions between multiple cell types, growth factors, inflammatory mediators and components of the extracellular matrix (ECM). Aberrant and uncontrolled wound healin...

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Veröffentlicht in:	Progress in retinal and eye research 2017-09, Vol.60, p.44-65
Hauptverfasser:	Shu, Daisy Y., Lovicu, Frank J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Transdifferentiation - physiology Epithelial-mesenchymal transition (EMT) Epithelial-Mesenchymal Transition - physiology Eye Diseases - physiopathology Fibrosis Fibrosis - physiopathology Humans Myofibroblast Myofibroblasts - physiology Ocular Signal Transduction - physiology Transforming Growth Factor beta - metabolism Transforming growth factor-beta (TGFβ) Wound healing Wound Healing - physiology
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