Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma

We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target safety and efficacy. Here, we show that GPC2 is a strong candidate immunotherapeutic target in this childhood cancer. We...

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Veröffentlicht in:	Cancer cell 2017-09, Vol.32 (3), p.295-309.e12
Hauptverfasser:	Bosse, Kristopher R., Raman, Pichai, Zhu, Zhongyu, Lane, Maria, Martinez, Daniel, Heitzeneder, Sabine, Rathi, Komal S., Kendsersky, Nathan M., Randall, Michael, Donovan, Laura, Morrissy, Sorana, Sussman, Robyn T., Zhelev, Doncho V., Feng, Yang, Wang, Yanping, Hwang, Jennifer, Lopez, Gonzalo, Harenza, Jo Lynne, Wei, Jun S., Pawel, Bruce, Bhatti, Tricia, Santi, Mariarita, Ganguly, Arupa, Khan, Javed, Marra, Marco A., Taylor, Michael D., Dimitrov, Dimiter S., Mackall, Crystal L., Maris, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neoplasm - metabolism antibody-drug conjugate Cell Death Cell Line, Tumor Cell Membrane - metabolism Cell Proliferation Child Gene Expression Regulation, Neoplastic Genome, Human glypican Glypicans - metabolism Humans Immunotherapy medulloblastoma Mice, Inbred NOD Mice, SCID Molecular Targeted Therapy MYCN N-Myc Proto-Oncogene Protein - metabolism neuroblastoma Neuroblastoma - genetics Neuroblastoma - immunology Neuroblastoma - pathology Neuroblastoma - therapy Oncogene Proteins - metabolism Risk Factors RNA, Messenger - genetics RNA, Messenger - metabolism
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