SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway

Background Estrone (E1), the major circulating estrogen in postmenopausal women, promotes estrogen-receptor positive (ER+) breast tumor growth and proliferation. Two major reactions contribute to E1 plasma concentrations, aromatase (CYP19A1) catalyzed E1 synthesis from androstenedione and steroid su...

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Veröffentlicht in:	Breast cancer research and treatment 2017-07, Vol.164 (1), p.189-199
Hauptverfasser:	Dudenkov, Tanda M., Ingle, James N., Buzdar, Aman U., Robson, Mark E., Kubo, Michiaki, Ibrahim-zada, Irada, Batzler, Anthony, Jenkins, Gregory D., Pietrzak, Tracy L., Carlson, Erin E., Barman, Poulami, Goetz, Matthew P., Northfelt, Donald W., Moreno-Aspita, Alvaro, Williard, Clark V., Kalari, Krishna R., Nakamura, Yusuke, Wang, Liewei, Weinshilboum, Richard M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Androstenedione Aromatase Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer genetics Cancer research Cytochrome P-450 Development and progression Epidemiology Estrogen receptors Estrogens Estrone Estrone - blood Estrone - genetics Female Genetic aspects Genetic Predisposition to Disease Genetic research Genome-wide association studies Genome-Wide Association Study Genomes Genomics Health aspects Humans Hydrolysis Medicine Medicine & Public Health Middle Aged Oncology Polymorphism, Single Nucleotide - genetics Post-menopause Postmenopausal women Postmenopause Single nucleotide polymorphisms Single-nucleotide polymorphism Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics Steroid sulfatase
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