Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II cells (AEC2s). Here we show that local lung h...

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Veröffentlicht in:	Nature cell biology 2017-08, Vol.19 (8), p.904-914
Hauptverfasser:	Xi, Ying, Kim, Thomas, Brumwell, Alexis N., Driver, Ian H., Wei, Ying, Tan, Victor, Jackson, Julia R., Xu, Jianming, Lee, Dong-Kee, Gotts, Jeffrey E., Matthay, Michael A., Shannon, John M., Chapman, Harold A., Vaughan, Andrew E.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/31 13/51 14 38 38/77 38/91 631/136/142 631/136/2091 631/532/489 631/80/86 Alveoli Animals Cancer Research Cell Biology Cell differentiation Cell Lineage Cell Movement Cell Proliferation Cell Transdifferentiation Cells, Cultured Clonal deletion Cytokeratin Developmental Biology Differentiation Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology Female Fibrosis Gene Expression Profiling Genotype Health aspects Humans Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia - pathology Hypoxia - virology Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Hypoxia-inducible factors Influenza Influenza A Virus, H1N1 Subtype - pathogenicity Influenza, Human - genetics Influenza, Human - metabolism Influenza, Human - pathology Influenza, Human - virology Keratin-5 - genetics Keratin-5 - metabolism Life Sciences Lungs Male Metaplasia Mice, Transgenic Migration Notch protein Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - metabolism Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Oxygen - metabolism Phenotype Phosphoproteins - genetics Phosphoproteins - metabolism Progenitor cells Protein C Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary Alveoli - virology Receptors, Notch - metabolism Regeneration Respiratory function Signal transduction Signaling Single-Cell Analysis SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem Cells Surfactant protein C Time Factors Trans-Activators - genetics Trans-Activators - metabolism Transcription Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Wnt protein Wnt Signaling Pathway β-Catenin
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