Genetic Landscape of a Cell
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic inter...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2010-01, Vol.327 (5964), p.425-431 |
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| creator | Costanzo, Michael Baryshnikova, Anastasia Bellay, Jeremy Kim, Yungil Spear, Eric D Sevier, Carolyn S Ding, Huiming Koh, Judice L.Y Toufighi, Kiana Mostafavi, Sara Prinz, Jeany St. Onge, Robert P VanderSluis, Benjamin Makhnevych, Taras Vizeacoumar, Franco J Alizadeh, Solmaz Bahr, Sondra Brost, Renee L Chen, Yiqun Cokol, Murat Deshpande, Raamesh Li, Zhijian Lin, Zhen-Yuan Liang, Wendy Marback, Michaela Paw, Jadine San Luis, Bryan-Joseph Shuteriqi, Ermira Tong, Amy Hin Yan van Dyk, Nydia Wallace, Iain M Whitney, Joseph A Weirauch, Matthew T Zhong, Guoqing Zhu, Hongwei Houry, Walid A Brudno, Michael Ragibizadeh, Sasan Papp, Balázs Pál, Csaba Roth, Frederick P Giaever, Guri Nislow, Corey Troyanskaya, Olga G Bussey, Howard Bader, Gary D Gingras, Anne-Claude Morris, Quaid D Kim, Philip M Kaiser, Chris A Myers, Chad L Andrews, Brenda J Boone, Charles |
| description | A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification. |
| doi_str_mv | 10.1126/science.1180823 |
| format | Article |
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A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1180823</identifier><identifier>PMID: 20093466</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Biological and medical sciences ; Cellular biology ; Computational Biology ; Cytogenetics ; Drug interactions ; Evolutionary genetics ; Fundamental and applied biological sciences. Psychology ; Gene Duplication ; Gene Expression Regulation, Fungal ; Gene interaction ; Gene Regulatory Networks ; Genes ; Genes, Fungal ; Genetic Fitness ; Genetic mapping ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genome, Fungal ; Genomics ; Genotype & phenotype ; Human genetics ; Medical genetics ; Metabolic Networks and Pathways ; Microbial genetics ; Mutation ; Protein Interaction Mapping ; Quantitative genetics ; Research Article ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae - physiology ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Thallophyta, bryophyta ; Vegetals and fungi ; Yeast</subject><ispartof>Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5964), p.425-431</ispartof><rights>Copyright 2010 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-86cee0a937a1ff8c91660ba18ac5c2b455fcc6aa9a6c7799c2e91a5f641d58b93</citedby><cites>FETCH-LOGICAL-c653t-86cee0a937a1ff8c91660ba18ac5c2b455fcc6aa9a6c7799c2e91a5f641d58b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40508589$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40508589$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22331953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20093466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costanzo, Michael</creatorcontrib><creatorcontrib>Baryshnikova, Anastasia</creatorcontrib><creatorcontrib>Bellay, Jeremy</creatorcontrib><creatorcontrib>Kim, Yungil</creatorcontrib><creatorcontrib>Spear, Eric D</creatorcontrib><creatorcontrib>Sevier, Carolyn S</creatorcontrib><creatorcontrib>Ding, Huiming</creatorcontrib><creatorcontrib>Koh, Judice L.Y</creatorcontrib><creatorcontrib>Toufighi, Kiana</creatorcontrib><creatorcontrib>Mostafavi, Sara</creatorcontrib><creatorcontrib>Prinz, Jeany</creatorcontrib><creatorcontrib>St. Onge, Robert P</creatorcontrib><creatorcontrib>VanderSluis, Benjamin</creatorcontrib><creatorcontrib>Makhnevych, Taras</creatorcontrib><creatorcontrib>Vizeacoumar, Franco J</creatorcontrib><creatorcontrib>Alizadeh, Solmaz</creatorcontrib><creatorcontrib>Bahr, Sondra</creatorcontrib><creatorcontrib>Brost, Renee L</creatorcontrib><creatorcontrib>Chen, Yiqun</creatorcontrib><creatorcontrib>Cokol, Murat</creatorcontrib><creatorcontrib>Deshpande, Raamesh</creatorcontrib><creatorcontrib>Li, Zhijian</creatorcontrib><creatorcontrib>Lin, Zhen-Yuan</creatorcontrib><creatorcontrib>Liang, Wendy</creatorcontrib><creatorcontrib>Marback, Michaela</creatorcontrib><creatorcontrib>Paw, Jadine</creatorcontrib><creatorcontrib>San Luis, Bryan-Joseph</creatorcontrib><creatorcontrib>Shuteriqi, Ermira</creatorcontrib><creatorcontrib>Tong, Amy Hin Yan</creatorcontrib><creatorcontrib>van Dyk, Nydia</creatorcontrib><creatorcontrib>Wallace, Iain M</creatorcontrib><creatorcontrib>Whitney, Joseph A</creatorcontrib><creatorcontrib>Weirauch, Matthew T</creatorcontrib><creatorcontrib>Zhong, Guoqing</creatorcontrib><creatorcontrib>Zhu, Hongwei</creatorcontrib><creatorcontrib>Houry, Walid A</creatorcontrib><creatorcontrib>Brudno, Michael</creatorcontrib><creatorcontrib>Ragibizadeh, Sasan</creatorcontrib><creatorcontrib>Papp, Balázs</creatorcontrib><creatorcontrib>Pál, Csaba</creatorcontrib><creatorcontrib>Roth, Frederick P</creatorcontrib><creatorcontrib>Giaever, Guri</creatorcontrib><creatorcontrib>Nislow, Corey</creatorcontrib><creatorcontrib>Troyanskaya, Olga G</creatorcontrib><creatorcontrib>Bussey, Howard</creatorcontrib><creatorcontrib>Bader, Gary D</creatorcontrib><creatorcontrib>Gingras, Anne-Claude</creatorcontrib><creatorcontrib>Morris, Quaid D</creatorcontrib><creatorcontrib>Kim, Philip M</creatorcontrib><creatorcontrib>Kaiser, Chris A</creatorcontrib><creatorcontrib>Myers, Chad L</creatorcontrib><creatorcontrib>Andrews, Brenda J</creatorcontrib><creatorcontrib>Boone, Charles</creatorcontrib><title>Genetic Landscape of a Cell</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification.</description><subject>Biological and medical sciences</subject><subject>Cellular biology</subject><subject>Computational Biology</subject><subject>Cytogenetics</subject><subject>Drug interactions</subject><subject>Evolutionary genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Duplication</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Gene interaction</subject><subject>Gene Regulatory Networks</subject><subject>Genes</subject><subject>Genes, Fungal</subject><subject>Genetic Fitness</subject><subject>Genetic mapping</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome, Fungal</subject><subject>Genomics</subject><subject>Genotype & phenotype</subject><subject>Human genetics</subject><subject>Medical genetics</subject><subject>Metabolic Networks and Pathways</subject><subject>Microbial genetics</subject><subject>Mutation</subject><subject>Protein Interaction Mapping</subject><subject>Quantitative genetics</subject><subject>Research Article</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae - physiology</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Thallophyta, bryophyta</subject><subject>Vegetals and fungi</subject><subject>Yeast</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEURS0EoqGwZoGgERLshj5_jr1BQhG0lSKxgK6tlxe7TDQZB3uCxL_HJUNa2LCyrXt85OfL2HMO7zgX5rxQFwYK9WDBCvmAzTg43TgB8iGbAUjTWGj1CXtSygagZk4-Ziei7qQyZsZeXIQhjB3NlzisC-EuzFOc43wR-v4pexSxL-HZtJ6y608fvy4um-Xni6vFh2VDRsuxsYZCAHSyRR6jJceNgRVyi6RJrJTWkcggOjTUts6RCI6jjkbxtbYrJ0_Z-4N3t19tw5rCMGbs_S53W8w_fcLO_50M3Td_k354bQCEVlXwdhLk9H0fyui3XaE6AQ4h7YuXRslWWPdfUHDhjG1NBV__A27SPg_1FyojjQCrdIXODxDlVEoO8fhkDv62Hj_V46d66o1X9yc98n_6qMCbCcBaRh8zDtSVO646uNO3opcHblPGlI-5Ag1W_x707JBHTB5vcnVcfxHAJfDWKcGV_AWS86pn</recordid><startdate>20100122</startdate><enddate>20100122</enddate><creator>Costanzo, Michael</creator><creator>Baryshnikova, Anastasia</creator><creator>Bellay, Jeremy</creator><creator>Kim, Yungil</creator><creator>Spear, Eric D</creator><creator>Sevier, Carolyn S</creator><creator>Ding, Huiming</creator><creator>Koh, Judice L.Y</creator><creator>Toufighi, Kiana</creator><creator>Mostafavi, Sara</creator><creator>Prinz, Jeany</creator><creator>St. Onge, Robert P</creator><creator>VanderSluis, Benjamin</creator><creator>Makhnevych, Taras</creator><creator>Vizeacoumar, Franco J</creator><creator>Alizadeh, Solmaz</creator><creator>Bahr, Sondra</creator><creator>Brost, Renee L</creator><creator>Chen, Yiqun</creator><creator>Cokol, Murat</creator><creator>Deshpande, Raamesh</creator><creator>Li, Zhijian</creator><creator>Lin, Zhen-Yuan</creator><creator>Liang, Wendy</creator><creator>Marback, Michaela</creator><creator>Paw, Jadine</creator><creator>San Luis, Bryan-Joseph</creator><creator>Shuteriqi, Ermira</creator><creator>Tong, Amy Hin Yan</creator><creator>van Dyk, Nydia</creator><creator>Wallace, Iain M</creator><creator>Whitney, Joseph A</creator><creator>Weirauch, Matthew T</creator><creator>Zhong, Guoqing</creator><creator>Zhu, Hongwei</creator><creator>Houry, Walid A</creator><creator>Brudno, Michael</creator><creator>Ragibizadeh, Sasan</creator><creator>Papp, Balázs</creator><creator>Pál, Csaba</creator><creator>Roth, Frederick P</creator><creator>Giaever, Guri</creator><creator>Nislow, Corey</creator><creator>Troyanskaya, Olga G</creator><creator>Bussey, Howard</creator><creator>Bader, Gary D</creator><creator>Gingras, Anne-Claude</creator><creator>Morris, Quaid D</creator><creator>Kim, Philip M</creator><creator>Kaiser, Chris A</creator><creator>Myers, Chad L</creator><creator>Andrews, Brenda J</creator><creator>Boone, Charles</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20100122</creationdate><title>Genetic Landscape of a Cell</title><author>Costanzo, Michael ; Baryshnikova, Anastasia ; Bellay, Jeremy ; Kim, Yungil ; Spear, Eric D ; Sevier, Carolyn S ; Ding, Huiming ; Koh, Judice L.Y ; Toufighi, Kiana ; Mostafavi, Sara ; Prinz, Jeany ; St. Onge, Robert P ; VanderSluis, Benjamin ; Makhnevych, Taras ; Vizeacoumar, Franco J ; Alizadeh, Solmaz ; Bahr, Sondra ; Brost, Renee L ; Chen, Yiqun ; Cokol, Murat ; Deshpande, Raamesh ; Li, Zhijian ; Lin, Zhen-Yuan ; Liang, Wendy ; Marback, Michaela ; Paw, Jadine ; San Luis, Bryan-Joseph ; Shuteriqi, Ermira ; Tong, Amy Hin Yan ; van Dyk, Nydia ; Wallace, Iain M ; Whitney, Joseph A ; Weirauch, Matthew T ; Zhong, Guoqing ; Zhu, Hongwei ; Houry, Walid A ; Brudno, Michael ; Ragibizadeh, Sasan ; Papp, Balázs ; Pál, Csaba ; Roth, Frederick P ; Giaever, Guri ; Nislow, Corey ; Troyanskaya, Olga G ; Bussey, Howard ; Bader, Gary D ; Gingras, Anne-Claude ; Morris, Quaid D ; Kim, Philip M ; Kaiser, Chris A ; Myers, Chad L ; Andrews, Brenda J ; Boone, Charles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-86cee0a937a1ff8c91660ba18ac5c2b455fcc6aa9a6c7799c2e91a5f641d58b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Cellular biology</topic><topic>Computational Biology</topic><topic>Cytogenetics</topic><topic>Drug interactions</topic><topic>Evolutionary genetics</topic><topic>Fundamental and applied biological sciences. 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Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costanzo, Michael</au><au>Baryshnikova, Anastasia</au><au>Bellay, Jeremy</au><au>Kim, Yungil</au><au>Spear, Eric D</au><au>Sevier, Carolyn S</au><au>Ding, Huiming</au><au>Koh, Judice L.Y</au><au>Toufighi, Kiana</au><au>Mostafavi, Sara</au><au>Prinz, Jeany</au><au>St. Onge, Robert P</au><au>VanderSluis, Benjamin</au><au>Makhnevych, Taras</au><au>Vizeacoumar, Franco J</au><au>Alizadeh, Solmaz</au><au>Bahr, Sondra</au><au>Brost, Renee L</au><au>Chen, Yiqun</au><au>Cokol, Murat</au><au>Deshpande, Raamesh</au><au>Li, Zhijian</au><au>Lin, Zhen-Yuan</au><au>Liang, Wendy</au><au>Marback, Michaela</au><au>Paw, Jadine</au><au>San Luis, Bryan-Joseph</au><au>Shuteriqi, Ermira</au><au>Tong, Amy Hin Yan</au><au>van Dyk, Nydia</au><au>Wallace, Iain M</au><au>Whitney, Joseph A</au><au>Weirauch, Matthew T</au><au>Zhong, Guoqing</au><au>Zhu, Hongwei</au><au>Houry, Walid A</au><au>Brudno, Michael</au><au>Ragibizadeh, Sasan</au><au>Papp, Balázs</au><au>Pál, Csaba</au><au>Roth, Frederick P</au><au>Giaever, Guri</au><au>Nislow, Corey</au><au>Troyanskaya, Olga G</au><au>Bussey, Howard</au><au>Bader, Gary D</au><au>Gingras, Anne-Claude</au><au>Morris, Quaid D</au><au>Kim, Philip M</au><au>Kaiser, Chris A</au><au>Myers, Chad L</au><au>Andrews, Brenda J</au><au>Boone, Charles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Landscape of a Cell</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2010-01-22</date><risdate>2010</risdate><volume>327</volume><issue>5964</issue><spage>425</spage><epage>431</epage><pages>425-431</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function. The global network identifies functional cross-connections between all bioprocesses, mapping a cellular wiring diagram of pleiotropy. Genetic interaction degree correlated with a number of different gene attributes, which may be informative about genetic network hubs in other organisms. We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>20093466</pmid><doi>10.1126/science.1180823</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5964), p.425-431 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5600254 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Biological and medical sciences Cellular biology Computational Biology Cytogenetics Drug interactions Evolutionary genetics Fundamental and applied biological sciences. Psychology Gene Duplication Gene Expression Regulation, Fungal Gene interaction Gene Regulatory Networks Genes Genes, Fungal Genetic Fitness Genetic mapping Genetics Genetics of eukaryotes. Biological and molecular evolution Genome, Fungal Genomics Genotype & phenotype Human genetics Medical genetics Metabolic Networks and Pathways Microbial genetics Mutation Protein Interaction Mapping Quantitative genetics Research Article Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Thallophyta, bryophyta Vegetals and fungi Yeast |
| title | Genetic Landscape of a Cell |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T21%3A15%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Landscape%20of%20a%20Cell&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Costanzo,%20Michael&rft.date=2010-01-22&rft.volume=327&rft.issue=5964&rft.spage=425&rft.epage=431&rft.pages=425-431&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1180823&rft_dat=%3Cjstor_pubme%3E40508589%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213620845&rft_id=info:pmid/20093466&rft_jstor_id=40508589&rfr_iscdi=true |