Tissue-type plasminogen activator regulates macrophage activation and innate immunity

Tissue-type plasminogen activator (tPA) is the major intravascular activator of fibrinolysis and a ligand for receptors involved in cell signaling. In cultured macrophages, tPA inhibits the response to lipopolysaccharide (LPS) by a pathway that apparently requires low-density lipoprotein receptor-re...

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Veröffentlicht in:	Blood 2017-09, Vol.130 (11), p.1364-1374
Hauptverfasser:	Mantuano, Elisabetta, Azmoon, Pardis, Brifault, Coralie, Banki, Michael A., Gilder, Andrew S., Campana, Wendy M., Gonias, Steven L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - drug effects Bone Marrow Cells - pathology Humans Immunity, Innate - drug effects Inflammation - immunology Inflammation - pathology Ligands Lipopolysaccharides Low Density Lipoprotein Receptor-Related Protein-1 - metabolism Macrophage Activation - drug effects Male Mice, Inbred C57BL Phosphorylation - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction - drug effects Thrombosis and Hemostasis Tissue Plasminogen Activator - pharmacology
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