Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial
Aim To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL‐cholesterol, triglycerides, glucose). Methods One hundred and ten periodontitis patients without...
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| Veröffentlicht in: | Journal of clinical periodontology 2017-08, Vol.44 (8), p.833-841 |
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| creator | Bizzarro, Sergio Velden, Ubele Teeuw, Wijnand J. Gerdes, Victor E. A. Loos, Bruno G. |
| description | Aim
To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL‐cholesterol, triglycerides, glucose).
Methods
One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post‐therapy. Number of patients with undiagnosed MetS was also determined.
Results
In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post‐therapy, systolic BP (p |
| doi_str_mv | 10.1111/jcpe.12763 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5599971</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1929428205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4483-d2a4b8b877913265adee5873be9038c97461da1cc95d97a81aada0648534b6a63</originalsourceid><addsrcrecordid>eNp9kc-L1DAUx4Mo7uzqxT9AAl5E6Jo0bdJ4WFiGWX-woAcFb-E1eeNkaJuadFyq_7ypsy7qwVxe4H345L18CXnC2TnP5-XejnjOSyXFPbLikrGC1fzzfbJigolCaqVPyGlKe8a4EkI8JCdlI0vOmFiRH5vtFu1Ew5aOGH1wYZigo9MOI4wzvfHTjqY5Tdh7S2GYfK4xtB66RMNAR4jQ44QxLYZ8gzZ0mUzz4GLo8RW9pBEGF3r_HR21nR-8XfwxGx6RB9vswce39Yx8utp8XL8prt-_fru-vC5sVTWicCVUbdM2SmkuSlmDQ6wbJVrUTDRWq0pyB9xaXTutoOEADpismlpUrQQpzsjF0Tse2h6dxWGK0Jkx-h7ibAJ483dn8DvzJXwzda21VjwLnt8KYvh6wDSZ3ieLXQcDhkMyXHOmtJRseevZP-g-HOKQ18tUqauyKVmdqRdHKv9lShG3d8NwZpZMzZKp-ZVphp_-Of4d-jvEDPAjcOM7nP-jMu_WHzZH6U_AQq8a</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1929428205</pqid></control><display><type>article</type><title>Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Bizzarro, Sergio ; Velden, Ubele ; Teeuw, Wijnand J. ; Gerdes, Victor E. A. ; Loos, Bruno G.</creator><creatorcontrib>Bizzarro, Sergio ; Velden, Ubele ; Teeuw, Wijnand J. ; Gerdes, Victor E. A. ; Loos, Bruno G.</creatorcontrib><description>Aim
To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL‐cholesterol, triglycerides, glucose).
Methods
One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post‐therapy. Number of patients with undiagnosed MetS was also determined.
Results
In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post‐therapy, systolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow‐up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self‐reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12‐month follow‐up (p = .383).
Conclusion
Although a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12763</identifier><identifier>PMID: 28621003</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Anti-Infective Agents - therapeutic use ; Antimicrobial agents ; antimicrobials ; Blood pressure ; Cholesterol ; Clinical trials ; Dentistry ; Female ; Health risk assessment ; High density lipoprotein ; Humans ; Male ; Metabolic syndrome ; Metabolic Syndrome - prevention & control ; Middle Aged ; Periodontal Diseases - microbiology ; Periodontal Diseases - therapy ; Periodontal Therapy ; Periodontitis ; Randomized Clinical Trial ; systolic blood pressure ; Triglycerides</subject><ispartof>Journal of clinical periodontology, 2017-08, Vol.44 (8), p.833-841</ispartof><rights>2017 The Authors. , Published by John Wiley & Sons Ltd.</rights><rights>2017 The Authors. Journal of Clinical Periodontology, Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4483-d2a4b8b877913265adee5873be9038c97461da1cc95d97a81aada0648534b6a63</citedby><cites>FETCH-LOGICAL-c4483-d2a4b8b877913265adee5873be9038c97461da1cc95d97a81aada0648534b6a63</cites><orcidid>0000-0002-5228-5998</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.12763$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.12763$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28621003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bizzarro, Sergio</creatorcontrib><creatorcontrib>Velden, Ubele</creatorcontrib><creatorcontrib>Teeuw, Wijnand J.</creatorcontrib><creatorcontrib>Gerdes, Victor E. A.</creatorcontrib><creatorcontrib>Loos, Bruno G.</creatorcontrib><title>Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL‐cholesterol, triglycerides, glucose).
Methods
One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post‐therapy. Number of patients with undiagnosed MetS was also determined.
Results
In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post‐therapy, systolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow‐up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self‐reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12‐month follow‐up (p = .383).
Conclusion
Although a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.</description><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antimicrobial agents</subject><subject>antimicrobials</subject><subject>Blood pressure</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Dentistry</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - prevention & control</subject><subject>Middle Aged</subject><subject>Periodontal Diseases - microbiology</subject><subject>Periodontal Diseases - therapy</subject><subject>Periodontal Therapy</subject><subject>Periodontitis</subject><subject>Randomized Clinical Trial</subject><subject>systolic blood pressure</subject><subject>Triglycerides</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc-L1DAUx4Mo7uzqxT9AAl5E6Jo0bdJ4WFiGWX-woAcFb-E1eeNkaJuadFyq_7ypsy7qwVxe4H345L18CXnC2TnP5-XejnjOSyXFPbLikrGC1fzzfbJigolCaqVPyGlKe8a4EkI8JCdlI0vOmFiRH5vtFu1Ew5aOGH1wYZigo9MOI4wzvfHTjqY5Tdh7S2GYfK4xtB66RMNAR4jQ44QxLYZ8gzZ0mUzz4GLo8RW9pBEGF3r_HR21nR-8XfwxGx6RB9vswce39Yx8utp8XL8prt-_fru-vC5sVTWicCVUbdM2SmkuSlmDQ6wbJVrUTDRWq0pyB9xaXTutoOEADpismlpUrQQpzsjF0Tse2h6dxWGK0Jkx-h7ibAJ483dn8DvzJXwzda21VjwLnt8KYvh6wDSZ3ieLXQcDhkMyXHOmtJRseevZP-g-HOKQ18tUqauyKVmdqRdHKv9lShG3d8NwZpZMzZKp-ZVphp_-Of4d-jvEDPAjcOM7nP-jMu_WHzZH6U_AQq8a</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Bizzarro, Sergio</creator><creator>Velden, Ubele</creator><creator>Teeuw, Wijnand J.</creator><creator>Gerdes, Victor E. A.</creator><creator>Loos, Bruno G.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5228-5998</orcidid></search><sort><creationdate>201708</creationdate><title>Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial</title><author>Bizzarro, Sergio ; Velden, Ubele ; Teeuw, Wijnand J. ; Gerdes, Victor E. A. ; Loos, Bruno G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4483-d2a4b8b877913265adee5873be9038c97461da1cc95d97a81aada0648534b6a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antimicrobial agents</topic><topic>antimicrobials</topic><topic>Blood pressure</topic><topic>Cholesterol</topic><topic>Clinical trials</topic><topic>Dentistry</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - prevention & control</topic><topic>Middle Aged</topic><topic>Periodontal Diseases - microbiology</topic><topic>Periodontal Diseases - therapy</topic><topic>Periodontal Therapy</topic><topic>Periodontitis</topic><topic>Randomized Clinical Trial</topic><topic>systolic blood pressure</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bizzarro, Sergio</creatorcontrib><creatorcontrib>Velden, Ubele</creatorcontrib><creatorcontrib>Teeuw, Wijnand J.</creatorcontrib><creatorcontrib>Gerdes, Victor E. A.</creatorcontrib><creatorcontrib>Loos, Bruno G.</creatorcontrib><collection>Wiley Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bizzarro, Sergio</au><au>Velden, Ubele</au><au>Teeuw, Wijnand J.</au><au>Gerdes, Victor E. A.</au><au>Loos, Bruno G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2017-08</date><risdate>2017</risdate><volume>44</volume><issue>8</issue><spage>833</spage><epage>841</epage><pages>833-841</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL‐cholesterol, triglycerides, glucose).
Methods
One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post‐therapy. Number of patients with undiagnosed MetS was also determined.
Results
In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post‐therapy, systolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow‐up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self‐reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12‐month follow‐up (p = .383).
Conclusion
Although a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>28621003</pmid><doi>10.1111/jcpe.12763</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5228-5998</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Anti-Infective Agents - therapeutic use Antimicrobial agents antimicrobials Blood pressure Cholesterol Clinical trials Dentistry Female Health risk assessment High density lipoprotein Humans Male Metabolic syndrome Metabolic Syndrome - prevention & control Middle Aged Periodontal Diseases - microbiology Periodontal Diseases - therapy Periodontal Therapy Periodontitis Randomized Clinical Trial systolic blood pressure Triglycerides |
| title | Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial |
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