Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography
The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these i...
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| creator | Beikoghli Kalkhoran, Siavash Hall, Andrew R. White, Ian J. Cooper, Jackie Fan, Qiao Ong, Sang‐Bing Hernández‐Reséndiz, Sauri Cabrera‐Fuentes, Hector Chinda, Kroekkiat Chakraborty, Bibhas Dorn, Gerald W. Yellon, Derek M. Hausenloy, Derek J. |
| description | The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these imaging parameters. Here, we use 3D electron tomography to show that MFN2‐deficient mitochondria are larger in volume, more elongated, and less rounded; have fewer mitochondria–jSR contacts, and an increase in the distance between mitochondria and jSR, when compared to WT mitochondria. In comparison to 2D electron microscopy, 3D electron tomography can provide further insights into mitochondrial morphology and the mitochondria–jSR complex in the adult heart.
The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these imaging parameters. Here, we use 3D electron tomography to show that MFN2‐deficient mitochondria are larger in volume, more elongated, and less rounded; have fewer mitochondria–jSR contacts, and an increase in the distance between mitochondria and jSR, when compared to WT mitochondria. |
| doi_str_mv | 10.14814/phy2.13437 |
| format | Article |
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The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these imaging parameters. Here, we use 3D electron tomography to show that MFN2‐deficient mitochondria are larger in volume, more elongated, and less rounded; have fewer mitochondria–jSR contacts, and an increase in the distance between mitochondria and jSR, when compared to WT mitochondria.</description><identifier>EISSN: 2051-817X</identifier><identifier>DOI: 10.14814/phy2.13437</identifier><identifier>PMID: 28904083</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>3D electron tomography ; Animals ; Cellular and Molecular Conditions, Disorders and Treatments ; Electron Microscope Tomography - methods ; Electron microscopy ; GTP Phosphohydrolases - deficiency ; GTP Phosphohydrolases - genetics ; Heart ; Imaging, Three-Dimensional - methods ; Membrane Physiology ; MFN2 KO ; Mice ; Mitochondria ; Mitochondria, Muscle - metabolism ; Mitochondria, Muscle - ultrastructure ; mitochondria–jSR junction ; Morphology ; Myocytes, Cardiac - metabolism ; Myocytes, Cardiac - ultrastructure ; Original Research ; Physiology ; Sarcoplasmic reticulum ; Sarcoplasmic Reticulum - metabolism ; Sarcoplasmic Reticulum - ultrastructure ; Tomography</subject><ispartof>Physiological reports, 2017-09, Vol.5 (17), p.e13437-n/a</ispartof><rights>2017 The Authors. published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.</rights><rights>2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4527-f99c0509938dea1101cbe8f8d98cad79cc24ef8ddcd6b43f568ee54d6bb6f8323</citedby><cites>FETCH-LOGICAL-c4527-f99c0509938dea1101cbe8f8d98cad79cc24ef8ddcd6b43f568ee54d6bb6f8323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28904083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beikoghli Kalkhoran, Siavash</creatorcontrib><creatorcontrib>Hall, Andrew R.</creatorcontrib><creatorcontrib>White, Ian J.</creatorcontrib><creatorcontrib>Cooper, Jackie</creatorcontrib><creatorcontrib>Fan, Qiao</creatorcontrib><creatorcontrib>Ong, Sang‐Bing</creatorcontrib><creatorcontrib>Hernández‐Reséndiz, Sauri</creatorcontrib><creatorcontrib>Cabrera‐Fuentes, Hector</creatorcontrib><creatorcontrib>Chinda, Kroekkiat</creatorcontrib><creatorcontrib>Chakraborty, Bibhas</creatorcontrib><creatorcontrib>Dorn, Gerald W.</creatorcontrib><creatorcontrib>Yellon, Derek M.</creatorcontrib><creatorcontrib>Hausenloy, Derek J.</creatorcontrib><title>Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography</title><title>Physiological reports</title><addtitle>Physiol Rep</addtitle><description>The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these imaging parameters. Here, we use 3D electron tomography to show that MFN2‐deficient mitochondria are larger in volume, more elongated, and less rounded; have fewer mitochondria–jSR contacts, and an increase in the distance between mitochondria and jSR, when compared to WT mitochondria. In comparison to 2D electron microscopy, 3D electron tomography can provide further insights into mitochondrial morphology and the mitochondria–jSR complex in the adult heart.
The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these imaging parameters. Here, we use 3D electron tomography to show that MFN2‐deficient mitochondria are larger in volume, more elongated, and less rounded; have fewer mitochondria–jSR contacts, and an increase in the distance between mitochondria and jSR, when compared to WT mitochondria.</description><subject>3D electron tomography</subject><subject>Animals</subject><subject>Cellular and Molecular Conditions, Disorders and Treatments</subject><subject>Electron Microscope Tomography - methods</subject><subject>Electron microscopy</subject><subject>GTP Phosphohydrolases - deficiency</subject><subject>GTP Phosphohydrolases - genetics</subject><subject>Heart</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Membrane Physiology</subject><subject>MFN2 KO</subject><subject>Mice</subject><subject>Mitochondria</subject><subject>Mitochondria, Muscle - metabolism</subject><subject>Mitochondria, Muscle - ultrastructure</subject><subject>mitochondria–jSR junction</subject><subject>Morphology</subject><subject>Myocytes, Cardiac - metabolism</subject><subject>Myocytes, Cardiac - ultrastructure</subject><subject>Original Research</subject><subject>Physiology</subject><subject>Sarcoplasmic reticulum</subject><subject>Sarcoplasmic Reticulum - metabolism</subject><subject>Sarcoplasmic Reticulum - ultrastructure</subject><subject>Tomography</subject><issn>2051-817X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1LxDAQxYMgKurJuwS8CLKaj6abXATxGwQ9KOgpZNPJbqRt1qRV9r83blXUg6fhMb95vOEhtEPJIS0kLY7mswU7pLzg4xW0wYigI0nHj-toO6VnQgglnCtSrKF1JvMkkm8gfZISpOTbKe5mgME5sF3CweHGd8H1eYMZrsB566G1C5z1B2iqvu7wDEzscL8852cY6nwcQyZCE6bR5DxbaNWZOsH259xEDxfn96dXo5vby-vTk5uRLQQbj5xSlgiiFJcVGEoJtROQTlZKWlONlbWsgCwrW5WTgjtRSgBRZDEpneSMb6LjwXfeTxqoLLRdNLWeR9-YuNDBeP170_qZnoZXLYRSspTZYP_TIIaXHlKnG58s1LVpIfRJ0xxNCsYFzejeH_Q59LHN7w0UUYyVmToYKBtDShHcdxhK9LIv_dGXXvaV6d2f-b_Zr6YywAbgzdew-M9L3109scH1HXPAo94</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Beikoghli Kalkhoran, Siavash</creator><creator>Hall, Andrew R.</creator><creator>White, Ian J.</creator><creator>Cooper, Jackie</creator><creator>Fan, Qiao</creator><creator>Ong, Sang‐Bing</creator><creator>Hernández‐Reséndiz, Sauri</creator><creator>Cabrera‐Fuentes, Hector</creator><creator>Chinda, Kroekkiat</creator><creator>Chakraborty, Bibhas</creator><creator>Dorn, Gerald W.</creator><creator>Yellon, Derek M.</creator><creator>Hausenloy, Derek J.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201709</creationdate><title>Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography</title><author>Beikoghli Kalkhoran, Siavash ; Hall, Andrew R. ; White, Ian J. ; Cooper, Jackie ; Fan, Qiao ; Ong, Sang‐Bing ; Hernández‐Reséndiz, Sauri ; Cabrera‐Fuentes, Hector ; Chinda, Kroekkiat ; Chakraborty, Bibhas ; Dorn, Gerald W. ; Yellon, Derek M. ; Hausenloy, Derek J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4527-f99c0509938dea1101cbe8f8d98cad79cc24ef8ddcd6b43f568ee54d6bb6f8323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>3D electron tomography</topic><topic>Animals</topic><topic>Cellular and Molecular Conditions, Disorders and Treatments</topic><topic>Electron Microscope Tomography - methods</topic><topic>Electron microscopy</topic><topic>GTP Phosphohydrolases - deficiency</topic><topic>GTP Phosphohydrolases - genetics</topic><topic>Heart</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Membrane Physiology</topic><topic>MFN2 KO</topic><topic>Mice</topic><topic>Mitochondria</topic><topic>Mitochondria, Muscle - metabolism</topic><topic>Mitochondria, Muscle - ultrastructure</topic><topic>mitochondria–jSR junction</topic><topic>Morphology</topic><topic>Myocytes, Cardiac - metabolism</topic><topic>Myocytes, Cardiac - ultrastructure</topic><topic>Original Research</topic><topic>Physiology</topic><topic>Sarcoplasmic reticulum</topic><topic>Sarcoplasmic Reticulum - metabolism</topic><topic>Sarcoplasmic Reticulum - ultrastructure</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beikoghli Kalkhoran, Siavash</creatorcontrib><creatorcontrib>Hall, Andrew R.</creatorcontrib><creatorcontrib>White, Ian J.</creatorcontrib><creatorcontrib>Cooper, Jackie</creatorcontrib><creatorcontrib>Fan, Qiao</creatorcontrib><creatorcontrib>Ong, Sang‐Bing</creatorcontrib><creatorcontrib>Hernández‐Reséndiz, Sauri</creatorcontrib><creatorcontrib>Cabrera‐Fuentes, Hector</creatorcontrib><creatorcontrib>Chinda, Kroekkiat</creatorcontrib><creatorcontrib>Chakraborty, Bibhas</creatorcontrib><creatorcontrib>Dorn, Gerald W.</creatorcontrib><creatorcontrib>Yellon, Derek M.</creatorcontrib><creatorcontrib>Hausenloy, Derek J.</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beikoghli Kalkhoran, Siavash</au><au>Hall, Andrew R.</au><au>White, Ian J.</au><au>Cooper, Jackie</au><au>Fan, Qiao</au><au>Ong, Sang‐Bing</au><au>Hernández‐Reséndiz, Sauri</au><au>Cabrera‐Fuentes, Hector</au><au>Chinda, Kroekkiat</au><au>Chakraborty, Bibhas</au><au>Dorn, Gerald W.</au><au>Yellon, Derek M.</au><au>Hausenloy, Derek J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography</atitle><jtitle>Physiological reports</jtitle><addtitle>Physiol Rep</addtitle><date>2017-09</date><risdate>2017</risdate><volume>5</volume><issue>17</issue><spage>e13437</spage><epage>n/a</epage><pages>e13437-n/a</pages><eissn>2051-817X</eissn><abstract>The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these imaging parameters. Here, we use 3D electron tomography to show that MFN2‐deficient mitochondria are larger in volume, more elongated, and less rounded; have fewer mitochondria–jSR contacts, and an increase in the distance between mitochondria and jSR, when compared to WT mitochondria. In comparison to 2D electron microscopy, 3D electron tomography can provide further insights into mitochondrial morphology and the mitochondria–jSR complex in the adult heart.
The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria–junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable to provide a 3D spatial assessment of these imaging parameters. Here, we use 3D electron tomography to show that MFN2‐deficient mitochondria are larger in volume, more elongated, and less rounded; have fewer mitochondria–jSR contacts, and an increase in the distance between mitochondria and jSR, when compared to WT mitochondria.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>28904083</pmid><doi>10.14814/phy2.13437</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3D electron tomography Animals Cellular and Molecular Conditions, Disorders and Treatments Electron Microscope Tomography - methods Electron microscopy GTP Phosphohydrolases - deficiency GTP Phosphohydrolases - genetics Heart Imaging, Three-Dimensional - methods Membrane Physiology MFN2 KO Mice Mitochondria Mitochondria, Muscle - metabolism Mitochondria, Muscle - ultrastructure mitochondria–jSR junction Morphology Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Original Research Physiology Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - ultrastructure Tomography |
| title | Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography |
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