The Impact of Young Age for Prognosis by Subtype in Women with Early Breast Cancer
Young age (≤40 years) use to be considered an independent risk factor for the prognosis of women with early-stage breast cancer. We conducted a retrospective analysis to investigate this claim in a population of young patients who were stratified by molecular subtype. We identified 2,125 women with...
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| Veröffentlicht in: | Scientific reports 2017-09, Vol.7 (1), p.11625-8, Article 11625 |
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| description | Young age (≤40 years) use to be considered an independent risk factor for the prognosis of women with early-stage breast cancer. We conducted a retrospective analysis to investigate this claim in a population of young patients who were stratified by molecular subtype. We identified 2,125 women with stage I to III breast cancer from the Fujian Medical University Union Hospital. Multivariable Cox proportional hazards models were used to analyze the relationship between age groups stratified by molecular subtype and 5-year disease-free survival (DFS), 5-year distant metastasis-free survival (DMFS), and 5-year breast cancer-specific survival (BCSS). Median follow-up time was 77 months. Patients ≤40 years of age presented with a significantly worse 5-year DFS and 5-year DMFS. In stratified analyses, young women with luminal A subtype disease were associated with a worse 5-year DFS, 5-year DMFS, and 5-year BCSS. Women with luminal B (Her2−) tumors showed a decrease in 5-year DFS and 5-year DMFS. Our findings support the hypothesis that young age seems to be an independent risk factor for the prognosis for breast cancer patients with the luminal A and luminal B (Her2−) subtypes but not in those with luminal B (Her2+), Her2 over-expression, and triple-negative disease. |
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We conducted a retrospective analysis to investigate this claim in a population of young patients who were stratified by molecular subtype. We identified 2,125 women with stage I to III breast cancer from the Fujian Medical University Union Hospital. Multivariable Cox proportional hazards models were used to analyze the relationship between age groups stratified by molecular subtype and 5-year disease-free survival (DFS), 5-year distant metastasis-free survival (DMFS), and 5-year breast cancer-specific survival (BCSS). Median follow-up time was 77 months. Patients ≤40 years of age presented with a significantly worse 5-year DFS and 5-year DMFS. In stratified analyses, young women with luminal A subtype disease were associated with a worse 5-year DFS, 5-year DMFS, and 5-year BCSS. Women with luminal B (Her2−) tumors showed a decrease in 5-year DFS and 5-year DMFS. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lian, Weibin</au><au>Fu, Fangmeng</au><au>Lin, Yuxiang</au><au>Lu, Minjun</au><au>Chen, Boyang</au><au>Yang, Peidong</au><au>Zeng, Bangwei</au><au>Huang, Meng</au><au>Wang, Chuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Young Age for Prognosis by Subtype in Women with Early Breast Cancer</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-09-14</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>11625</spage><epage>8</epage><pages>11625-8</pages><artnum>11625</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Young age (≤40 years) use to be considered an independent risk factor for the prognosis of women with early-stage breast cancer. We conducted a retrospective analysis to investigate this claim in a population of young patients who were stratified by molecular subtype. We identified 2,125 women with stage I to III breast cancer from the Fujian Medical University Union Hospital. Multivariable Cox proportional hazards models were used to analyze the relationship between age groups stratified by molecular subtype and 5-year disease-free survival (DFS), 5-year distant metastasis-free survival (DMFS), and 5-year breast cancer-specific survival (BCSS). Median follow-up time was 77 months. Patients ≤40 years of age presented with a significantly worse 5-year DFS and 5-year DMFS. In stratified analyses, young women with luminal A subtype disease were associated with a worse 5-year DFS, 5-year DMFS, and 5-year BCSS. Women with luminal B (Her2−) tumors showed a decrease in 5-year DFS and 5-year DMFS. 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| subjects | 14/32 631/67/1347 692/4028/67/1347 Adult Age Age Factors Aged Biomarkers, Tumor Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - etiology Breast Neoplasms - pathology Breast Neoplasms - therapy Combined Modality Therapy ErbB-2 protein Female Health risk assessment Humanities and Social Sciences Humans Medical prognosis Metastases Middle Aged multidisciplinary Neoplasm Grading Neoplasm Staging Overexpression Prognosis Proportional Hazards Models Risk factors Science Science (multidisciplinary) Survival Treatment Outcome Tumors Womens health Young Adult |
| title | The Impact of Young Age for Prognosis by Subtype in Women with Early Breast Cancer |
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