High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1

Although much is known about transcriptional networks that control embryonic stem cell (ESC) self-renewal and differentiation, the metabolic regulation of ESC is less clear. Autophagy is a catabolic process that is activated under both stress and normal conditions to degrade damaged organelles and a...

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Veröffentlicht in:	Cell death and differentiation 2017-10, Vol.24 (10), p.1672-1680
Hauptverfasser:	Liu, Pinglei, Liu, Kun, Gu, Haifeng, Wang, Weixu, Gong, Jiaqi, Zhu, Yingjie, Zhao, Qian, Cao, Jiani, Han, Chunseng, Gao, Fei, Chen, Quan, Li, Wei, Jiao, Jianwei, Hu, Baoyang, Zhou, Qi, Zhao, Tongbiao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/28 45/15 45/41 631/80/39/2346 64/60 692/308/2171 82/80 Animals Apoptosis Autophagy Autophagy - genetics Biochemistry Biomedical and Life Sciences Catabolism Cell Biology Cell Cycle Analysis Cell Differentiation - genetics Cell Line Cell Self Renewal - genetics Cell self-renewal Flux Forkhead Box Protein O1 - genetics Forkhead protein FOXO1 protein Gene Expression Regulation - genetics Gene Regulatory Networks - genetics Homeostasis Life Sciences Mice Mitochondria Molecular machines Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism Organelles Original Paper Phagocytosis Pluripotency Pluripotent Stem Cells - cytology Stem Cells Tapering
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