FAS apoptotic inhibitory molecule 2 is a stress-induced intrinsic neuroprotective factor in the retina

We report the neuroprotective role of FAS apoptotic inhibitory molecule 2 (FAIM2), an inhibitor of the FAS signaling pathway, during stress-induced photoreceptor apoptosis. Retinal detachment resulted in increased FAIM2 levels in photoreceptors with higher amounts detected at the tips of outer segme...

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Veröffentlicht in:	Cell death and differentiation 2017-10, Vol.24 (10), p.1799-1810
Hauptverfasser:	Pawar, Mercy, Busov, Boris, Chandrasekhar, Aaruran, Yao, Jingyu, Zacks, David N, Besirli, Cagri G
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 14/63 38/39 631/378 64/110 64/60 692/308/1426 82/29 82/80 Activation Animals Apoptosis Apoptosis - physiology Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cell Death - physiology Fas Ligand Protein - metabolism fas Receptor - metabolism Hsp90 protein Intrinsic Factor - metabolism JNK protein Life Sciences Membrane Proteins - metabolism Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - metabolism Neuroprotection Original Paper p53 Protein Phosphorylation Photoreceptor Cells - metabolism Photoreceptors Proteasomes Retina Retina - metabolism Signal transduction Stem Cells
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