p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis

The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of human cancers are associated with the loss of p53 functions, where p53 often accumulates in the nucleus as well as in cytoplasm. Although it has been previously suggested that amyloid formation could be a cau...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death and differentiation 2017-10, Vol.24 (10), p.1784-1798
Hauptverfasser:	Ghosh, Saikat, Salot, Shimul, Sengupta, Shinjinee, Navalkar, Ambuja, Ghosh, Dhiman, Jacob, Reeba, Das, Subhadeep, Kumar, Rakesh, Jha, Narendra Nath, Sahay, Shruti, Mehra, Surabhi, Mohite, Ganesh M, Ghosh, Santanu K, Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Chaudhari, Pradip, Maji, Samir K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/56 631/80/470/2284 Amyloid - metabolism Amyloidogenesis Animals Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cytoplasm Fibrils Humans Life Sciences Mice Molecular structure Mutation - genetics Neoplasms - metabolism Neoplasms - pathology Nuclei Original Paper p53 Protein Prions - metabolism Protein Binding - physiology Protein Folding Stem Cells Structure-function relationships Transcription Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors β-Amyloid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!