Synchrotron-based ν-XRF mapping and μ-FTIR microscopy enable to look into the fate and effects of tattoo pigments in human skin
The increasing prevalence of tattoos provoked safety concerns with respect to particle distribution and effects inside the human body. We used skin and lymphatic tissues from human corpses to address local biokinetics by means of synchrotron X-ray fluorescence (XRF) techniques at both the micro (μ)...
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| Veröffentlicht in: | Scientific reports 2017-09, Vol.7 (1), p.11395-12, Article 11395 |
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| creator | Schreiver, Ines Hesse, Bernhard Seim, Christian Castillo-Michel, Hiram Villanova, Julie Laux, Peter Dreiack, Nadine Penning, Randolf Tucoulou, Remi Cotte, Marine Luch, Andreas |
| description | The increasing prevalence of tattoos provoked safety concerns with respect to particle distribution and effects inside the human body. We used skin and lymphatic tissues from human corpses to address local biokinetics by means of synchrotron X-ray fluorescence (XRF) techniques at both the micro (μ) and nano (ν) scale. Additional advanced mass spectrometry-based methodology enabled to demonstrate simultaneous transport of organic pigments, heavy metals and titanium dioxide from skin to regional lymph nodes. Among these compounds, organic pigments displayed the broadest size range with smallest species preferentially reaching the lymph nodes. Using synchrotron μ-FTIR analysis we were also able to detect ultrastructural changes of the tissue adjacent to tattoo particles through altered amide I α-helix to β-sheet protein ratios and elevated lipid contents. Altogether we report strong evidence for both migration and long-term deposition of toxic elements and tattoo pigments as well as for conformational alterations of biomolecules that likely contribute to cutaneous inflammation and other adversities upon tattooing. |
| doi_str_mv | 10.1038/s41598-017-11721-z |
| format | Article |
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We used skin and lymphatic tissues from human corpses to address local biokinetics by means of synchrotron X-ray fluorescence (XRF) techniques at both the micro (μ) and nano (ν) scale. Additional advanced mass spectrometry-based methodology enabled to demonstrate simultaneous transport of organic pigments, heavy metals and titanium dioxide from skin to regional lymph nodes. Among these compounds, organic pigments displayed the broadest size range with smallest species preferentially reaching the lymph nodes. Using synchrotron μ-FTIR analysis we were also able to detect ultrastructural changes of the tissue adjacent to tattoo particles through altered amide I α-helix to β-sheet protein ratios and elevated lipid contents. 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We used skin and lymphatic tissues from human corpses to address local biokinetics by means of synchrotron X-ray fluorescence (XRF) techniques at both the micro (μ) and nano (ν) scale. Additional advanced mass spectrometry-based methodology enabled to demonstrate simultaneous transport of organic pigments, heavy metals and titanium dioxide from skin to regional lymph nodes. Among these compounds, organic pigments displayed the broadest size range with smallest species preferentially reaching the lymph nodes. Using synchrotron μ-FTIR analysis we were also able to detect ultrastructural changes of the tissue adjacent to tattoo particles through altered amide I α-helix to β-sheet protein ratios and elevated lipid contents. 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chemistry</topic><topic>Heavy metals</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic system</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Microscopy</topic><topic>Migration</topic><topic>multidisciplinary</topic><topic>Organometallic Compounds - chemistry</topic><topic>Particle Size</topic><topic>Pigments</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Skin</topic><topic>Skin - pathology</topic><topic>Skin Pigmentation</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Tattooing - methods</topic><topic>Tattoos</topic><topic>Titanium dioxide</topic><topic>X-ray fluorescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schreiver, Ines</creatorcontrib><creatorcontrib>Hesse, Bernhard</creatorcontrib><creatorcontrib>Seim, Christian</creatorcontrib><creatorcontrib>Castillo-Michel, Hiram</creatorcontrib><creatorcontrib>Villanova, Julie</creatorcontrib><creatorcontrib>Laux, Peter</creatorcontrib><creatorcontrib>Dreiack, Nadine</creatorcontrib><creatorcontrib>Penning, Randolf</creatorcontrib><creatorcontrib>Tucoulou, Remi</creatorcontrib><creatorcontrib>Cotte, Marine</creatorcontrib><creatorcontrib>Luch, Andreas</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schreiver, Ines</au><au>Hesse, Bernhard</au><au>Seim, Christian</au><au>Castillo-Michel, Hiram</au><au>Villanova, Julie</au><au>Laux, Peter</au><au>Dreiack, Nadine</au><au>Penning, Randolf</au><au>Tucoulou, Remi</au><au>Cotte, Marine</au><au>Luch, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synchrotron-based ν-XRF mapping and μ-FTIR microscopy enable to look into the fate and effects of tattoo pigments in human skin</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-09-12</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>11395</spage><epage>12</epage><pages>11395-12</pages><artnum>11395</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The increasing prevalence of tattoos provoked safety concerns with respect to particle distribution and effects inside the human body. We used skin and lymphatic tissues from human corpses to address local biokinetics by means of synchrotron X-ray fluorescence (XRF) techniques at both the micro (μ) and nano (ν) scale. Additional advanced mass spectrometry-based methodology enabled to demonstrate simultaneous transport of organic pigments, heavy metals and titanium dioxide from skin to regional lymph nodes. Among these compounds, organic pigments displayed the broadest size range with smallest species preferentially reaching the lymph nodes. Using synchrotron μ-FTIR analysis we were also able to detect ultrastructural changes of the tissue adjacent to tattoo particles through altered amide I α-helix to β-sheet protein ratios and elevated lipid contents. Altogether we report strong evidence for both migration and long-term deposition of toxic elements and tattoo pigments as well as for conformational alterations of biomolecules that likely contribute to cutaneous inflammation and other adversities upon tattooing.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28900193</pmid><doi>10.1038/s41598-017-11721-z</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9313-7193</orcidid><orcidid>https://orcid.org/0000-0002-4949-588X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/250/2503 639/638/11/942 692/308/575 692/499 Biological Transport Coloring Agents - chemistry Heavy metals Humanities and Social Sciences Humans Life Sciences Lymph nodes Lymph Nodes - pathology Lymphatic system Mass spectrometry Mass spectroscopy Microscopy Migration multidisciplinary Organometallic Compounds - chemistry Particle Size Pigments Science Science (multidisciplinary) Skin Skin - pathology Skin Pigmentation Spectroscopy, Fourier Transform Infrared Tattooing - methods Tattoos Titanium dioxide X-ray fluorescence |
| title | Synchrotron-based ν-XRF mapping and μ-FTIR microscopy enable to look into the fate and effects of tattoo pigments in human skin |
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