Metoprolol‐pridopidine drug–drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's disease

Aims Pridopidine is an oral drug in clinical development for treatment of patients with Huntington's disease. This study examined the interactions of pridopidine with in vitro cytochrome P450 activity and characterized the effects of pridopidine on CYP2D6 activity in healthy volunteers using me...

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Veröffentlicht in:	British journal of clinical pharmacology 2017-10, Vol.83 (10), p.2214-2224
Hauptverfasser:	Rabinovich‐Guilatt, Laura, Steiner, Lilach, Hallak, Hussein, Pastino, Gina, Muglia, Pierandrea, Spiegelstein, Ofer
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Cells, Cultured Cross-Over Studies CYP2D6 Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 CYP2D6 Inhibitors - pharmacology Cytochrome P-450 CYP2D6 Inhibitors - therapeutic use Dextromethorphan - pharmacology Drug Interactions Female Ferricyanides - pharmacology Food-Drug Interactions Healthy Volunteers Hepatocytes Humans Huntington Disease - drug therapy Male Metoprolol - pharmacology Microsomes, Liver Middle Aged Piperidines - pharmacology Piperidines - therapeutic use pridopidine TV‐45065
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