Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

Using LC/qTOF-MS we detected lumisterol, 20-hydroxylumisterol, 22-hydroxylumisterol, 24-hydroxylumisterol, 20,22-dihydroxylumisterol, pregnalumisterol, 17-hydroxypregnalumisterol and 17,20-dihydroxypregnalumisterol in human serum and epidermis, and the porcine adrenal gland. The hydroxylumisterols i...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.11434-17, Article 11434
Hauptverfasser:	Slominski, Andrzej T., Kim, Tae-Kang, Hobrath, Judith V., Janjetovic, Zorica, Oak, Allen S. W., Postlethwaite, Arnold, Lin, Zongtao, Li, Wei, Takeda, Yukimasa, Jetten, Anton M., Tuckey, Robert C.
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 13 13/106 631/45/287/1197 692/163 Adrenal glands Agar Animals Biological activity Biomarkers Cancer Cell Line, Tumor Cell proliferation Chromatography, Liquid Dose-Response Relationship, Drug Drug dosages Epidermis Epidermis - drug effects Epidermis - metabolism Ergosterol - chemistry Ergosterol - metabolism Ergosterol - pharmacology Humanities and Social Sciences Humans Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Melanoma Metabolic Networks and Pathways - drug effects Metabolites Models, Molecular Molecular Conformation Molecular modelling Molecular Structure multidisciplinary Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Receptors, Calcitriol - chemistry Receptors, Calcitriol - metabolism Science Science (multidisciplinary) Skin Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Swine Transcription Translocation Vitamin D receptors
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