Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers

Summary Reduced neurogenesis in the aging mammalian hippocampus has been linked to cognitive deficits and increased risk of dementia. We utilized postmortem human hippocampal tissue from 26 subjects aged 18–88 years to investigate changes in expression of six genes representing different stages of n...

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Veröffentlicht in:	Aging cell 2017-10, Vol.16 (5), p.1195-1199
Hauptverfasser:	Mathews, Kathryn J., Allen, Katherine M., Boerrigter, Danny, Ball, Helen, Shannon Weickert, Cynthia, Double, Kay L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Aging Analysis Brain Cell Differentiation Cell Proliferation cognition Cognitive ability Dementia disorders doublecortin Doublecortin protein Female Gene Expression Regulation, Developmental Genes Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism healthy aging Healthy Aging - genetics Healthy Aging - metabolism Hippocampus Hippocampus - growth & development Hippocampus - metabolism Humans Ki-67 Antigen - genetics Ki-67 Antigen - metabolism Ki67 Life span Male Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Middle Aged mRNA Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurogenesis Neurogenesis - genetics Neuronal-glial interactions Neurons Neurons - cytology Neurons - metabolism Neuropeptides - genetics Neuropeptides - metabolism RNA Short Take Short Takes Stem cell research Stem cells T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism
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