Stalled replication forks generate a distinct mutational signature in yeast

Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying cause of aging and tumorigenesis. The molecular mechanisms of DNA replication-associate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-09, Vol.114 (36), p.9665-9670
Hauptverfasser:	Larsen, Nicolai B., Liberti, Sascha E., Vogel, Ivan, Jørgensen, Signe W., Hickson, Ian D., Mankouri, Hocine W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Aging Aging (artificial) Biological Sciences Bloom's syndrome Cancer Deoxyribonucleic acid DNA DNA biosynthesis DNA repair DNA Replication - genetics DNA, Fungal - genetics DNA, Fungal - metabolism DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Gene sequencing Genes, Reporter Genetic diversity Genetic Engineering Genomes Homologous recombination Homologous recombination repair Homology Humans In vivo methods and tests Intermediates Models, Biological Molecular modelling Mosaicism Mutagenesis Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleotide sequence Organisms Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinational DNA Repair RecQ Helicases - genetics RecQ Helicases - metabolism Repair Replication Replication forks Replication Origin Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Single-stranded DNA Stalling Studies Tumorigenesis Yeast
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