Expression of redox sensing factor Nrf2 in lung macrophages and type II pneumocytes as a prognostic factor in pneumothorax recurrence
Primary spontaneous pneumothorax (PSP) is a common clinical problem. However, PSP recurrence is still a major concern. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a protective role against oxidative airway diseases. The aim was to investigate the role of Nrf2 in PSP patients and its cor...
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| Veröffentlicht in: | Journal of thoracic disease 2017-08, Vol.9 (8), p.2498-2509 |
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| creator | Chiu, Wen-Chin Lee, Yen-Lung Chou, Shah-Hwa Lee, Yi-Chen Su, Yu-Han Hou, Yi-An Chiang, Hung-Hsing Yin, Hsin-Ling Hu, Stephen Chu-Sung Huang, Ming-Yii Huang, Chih-Jen Yuan, Shyng-Shiou F |
| description | Primary spontaneous pneumothorax (PSP) is a common clinical problem. However, PSP recurrence is still a major concern. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a protective role against oxidative airway diseases. The aim was to investigate the role of Nrf2 in PSP patients and its correlation with recurrence.
Eighty-nine patients were enrolled and received wedge resection of lung with identifiable blebs. Nrf2 expression in resected lung tissues was determined by immunohistochemistry (IHC) and correlated with clinicopathological variables. The prognostic value of Nrf2 for incidence-of-recurrence was determined by Kaplan-Meier estimates and the significance of differences was evaluated by the log-rank test.
Nrf2 staining was predominantly observed in alveolar macrophages and type II pneumocytes of PSP patients and correlated with recurrence (P |
| doi_str_mv | 10.21037/jtd.2017.07.13 |
| format | Article |
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Eighty-nine patients were enrolled and received wedge resection of lung with identifiable blebs. Nrf2 expression in resected lung tissues was determined by immunohistochemistry (IHC) and correlated with clinicopathological variables. The prognostic value of Nrf2 for incidence-of-recurrence was determined by Kaplan-Meier estimates and the significance of differences was evaluated by the log-rank test.
Nrf2 staining was predominantly observed in alveolar macrophages and type II pneumocytes of PSP patients and correlated with recurrence (P<0.001 and P=0.001, respectively) and PSP location (macrophages, P=0.013). High Nrf2 expression was correlated with better incidence-of-recurrence (macrophages, P=0.003; type II pneumocytes, P=0.003). Moreover, incidence-of-recurrence was better in patients with higher Nrf2 expression, especially those in the age ≤20, male, and non-smoking groups (macrophages, P=0.009, 0.006, and 0.012; type II pneumocytes, P=0.003, 0.011, and 0.010, respectively).
High Nrf2 expression in alveolar macrophages and type II pneumocytes was significantly associated with the decreased recurrence risk and was the independent factor predicting a better incidence-of-recurrence in PSP. Our results suggest that Nrf2 activation in high risk patients may be a potential target for reducing PSP recurrence.</description><identifier>ISSN: 2072-1439</identifier><identifier>EISSN: 2077-6624</identifier><identifier>DOI: 10.21037/jtd.2017.07.13</identifier><identifier>PMID: 28932556</identifier><language>eng</language><publisher>China: AME Publishing Company</publisher><subject>Original</subject><ispartof>Journal of thoracic disease, 2017-08, Vol.9 (8), p.2498-2509</ispartof><rights>2017 Journal of Thoracic Disease. All rights reserved. 2017 Journal of Thoracic Disease.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-eb3c87a21030080fee2465eea0f1ffcddc5e95e89cd0bfd0c3c7a4b066a205363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594132/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594132/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28932556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiu, Wen-Chin</creatorcontrib><creatorcontrib>Lee, Yen-Lung</creatorcontrib><creatorcontrib>Chou, Shah-Hwa</creatorcontrib><creatorcontrib>Lee, Yi-Chen</creatorcontrib><creatorcontrib>Su, Yu-Han</creatorcontrib><creatorcontrib>Hou, Yi-An</creatorcontrib><creatorcontrib>Chiang, Hung-Hsing</creatorcontrib><creatorcontrib>Yin, Hsin-Ling</creatorcontrib><creatorcontrib>Hu, Stephen Chu-Sung</creatorcontrib><creatorcontrib>Huang, Ming-Yii</creatorcontrib><creatorcontrib>Huang, Chih-Jen</creatorcontrib><creatorcontrib>Yuan, Shyng-Shiou F</creatorcontrib><title>Expression of redox sensing factor Nrf2 in lung macrophages and type II pneumocytes as a prognostic factor in pneumothorax recurrence</title><title>Journal of thoracic disease</title><addtitle>J Thorac Dis</addtitle><description>Primary spontaneous pneumothorax (PSP) is a common clinical problem. However, PSP recurrence is still a major concern. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a protective role against oxidative airway diseases. The aim was to investigate the role of Nrf2 in PSP patients and its correlation with recurrence.
Eighty-nine patients were enrolled and received wedge resection of lung with identifiable blebs. Nrf2 expression in resected lung tissues was determined by immunohistochemistry (IHC) and correlated with clinicopathological variables. The prognostic value of Nrf2 for incidence-of-recurrence was determined by Kaplan-Meier estimates and the significance of differences was evaluated by the log-rank test.
Nrf2 staining was predominantly observed in alveolar macrophages and type II pneumocytes of PSP patients and correlated with recurrence (P<0.001 and P=0.001, respectively) and PSP location (macrophages, P=0.013). High Nrf2 expression was correlated with better incidence-of-recurrence (macrophages, P=0.003; type II pneumocytes, P=0.003). Moreover, incidence-of-recurrence was better in patients with higher Nrf2 expression, especially those in the age ≤20, male, and non-smoking groups (macrophages, P=0.009, 0.006, and 0.012; type II pneumocytes, P=0.003, 0.011, and 0.010, respectively).
High Nrf2 expression in alveolar macrophages and type II pneumocytes was significantly associated with the decreased recurrence risk and was the independent factor predicting a better incidence-of-recurrence in PSP. Our results suggest that Nrf2 activation in high risk patients may be a potential target for reducing PSP recurrence.</description><subject>Original</subject><issn>2072-1439</issn><issn>2077-6624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkU1PJCEQholxo8b1vDfD0UuPfDQwfdlkY1ydxOjFPROGLmbadEMLtJn5Af7vZRw1SiqBFA9vFfUi9IuSGaOEq8un3M4YoWpG1IzyA3TCiFKVlKw-fDuzita8OUZnKT2RsiRhTKkjdMzmDWdCyBP0er0ZI6TUBY-DwxHasMEJfOr8Cjtjc4j4PjqGO4_7qeQGY2MY12YFCRvf4rwdAS8WePQwDcFu8y5fAo8xrHxIubMfOkViT-V1iGZTitkpRvAWfqIfzvQJzt73U_Tv7_Xj1W1193CzuPpzV1ne8FzBktu5MrvPEzInDoDVUgAY4qhztm2tgEbAvLEtWbqWWG6VqZdESsOI4JKfot973XFaDtBa8DmaXo-xG0zc6mA6_f3Gd2u9Ci9aiKamnBWBi3eBGJ4nSFkPXbLQ98ZDmJKmO0yW6YqCXu7RMq-UIrjPMpToN_908U_v_NNEacrLi_Ov3X3yH27x_zuOmxM</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Chiu, Wen-Chin</creator><creator>Lee, Yen-Lung</creator><creator>Chou, Shah-Hwa</creator><creator>Lee, Yi-Chen</creator><creator>Su, Yu-Han</creator><creator>Hou, Yi-An</creator><creator>Chiang, Hung-Hsing</creator><creator>Yin, Hsin-Ling</creator><creator>Hu, Stephen Chu-Sung</creator><creator>Huang, Ming-Yii</creator><creator>Huang, Chih-Jen</creator><creator>Yuan, Shyng-Shiou F</creator><general>AME Publishing Company</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201708</creationdate><title>Expression of redox sensing factor Nrf2 in lung macrophages and type II pneumocytes as a prognostic factor in pneumothorax recurrence</title><author>Chiu, Wen-Chin ; Lee, Yen-Lung ; Chou, Shah-Hwa ; Lee, Yi-Chen ; Su, Yu-Han ; Hou, Yi-An ; Chiang, Hung-Hsing ; Yin, Hsin-Ling ; Hu, Stephen Chu-Sung ; Huang, Ming-Yii ; Huang, Chih-Jen ; Yuan, Shyng-Shiou F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-eb3c87a21030080fee2465eea0f1ffcddc5e95e89cd0bfd0c3c7a4b066a205363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Chiu, Wen-Chin</creatorcontrib><creatorcontrib>Lee, Yen-Lung</creatorcontrib><creatorcontrib>Chou, Shah-Hwa</creatorcontrib><creatorcontrib>Lee, Yi-Chen</creatorcontrib><creatorcontrib>Su, Yu-Han</creatorcontrib><creatorcontrib>Hou, Yi-An</creatorcontrib><creatorcontrib>Chiang, Hung-Hsing</creatorcontrib><creatorcontrib>Yin, Hsin-Ling</creatorcontrib><creatorcontrib>Hu, Stephen Chu-Sung</creatorcontrib><creatorcontrib>Huang, Ming-Yii</creatorcontrib><creatorcontrib>Huang, Chih-Jen</creatorcontrib><creatorcontrib>Yuan, Shyng-Shiou F</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of thoracic disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiu, Wen-Chin</au><au>Lee, Yen-Lung</au><au>Chou, Shah-Hwa</au><au>Lee, Yi-Chen</au><au>Su, Yu-Han</au><au>Hou, Yi-An</au><au>Chiang, Hung-Hsing</au><au>Yin, Hsin-Ling</au><au>Hu, Stephen Chu-Sung</au><au>Huang, Ming-Yii</au><au>Huang, Chih-Jen</au><au>Yuan, Shyng-Shiou F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of redox sensing factor Nrf2 in lung macrophages and type II pneumocytes as a prognostic factor in pneumothorax recurrence</atitle><jtitle>Journal of thoracic disease</jtitle><addtitle>J Thorac Dis</addtitle><date>2017-08</date><risdate>2017</risdate><volume>9</volume><issue>8</issue><spage>2498</spage><epage>2509</epage><pages>2498-2509</pages><issn>2072-1439</issn><eissn>2077-6624</eissn><abstract>Primary spontaneous pneumothorax (PSP) is a common clinical problem. However, PSP recurrence is still a major concern. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a protective role against oxidative airway diseases. The aim was to investigate the role of Nrf2 in PSP patients and its correlation with recurrence.
Eighty-nine patients were enrolled and received wedge resection of lung with identifiable blebs. Nrf2 expression in resected lung tissues was determined by immunohistochemistry (IHC) and correlated with clinicopathological variables. The prognostic value of Nrf2 for incidence-of-recurrence was determined by Kaplan-Meier estimates and the significance of differences was evaluated by the log-rank test.
Nrf2 staining was predominantly observed in alveolar macrophages and type II pneumocytes of PSP patients and correlated with recurrence (P<0.001 and P=0.001, respectively) and PSP location (macrophages, P=0.013). High Nrf2 expression was correlated with better incidence-of-recurrence (macrophages, P=0.003; type II pneumocytes, P=0.003). Moreover, incidence-of-recurrence was better in patients with higher Nrf2 expression, especially those in the age ≤20, male, and non-smoking groups (macrophages, P=0.009, 0.006, and 0.012; type II pneumocytes, P=0.003, 0.011, and 0.010, respectively).
High Nrf2 expression in alveolar macrophages and type II pneumocytes was significantly associated with the decreased recurrence risk and was the independent factor predicting a better incidence-of-recurrence in PSP. Our results suggest that Nrf2 activation in high risk patients may be a potential target for reducing PSP recurrence.</abstract><cop>China</cop><pub>AME Publishing Company</pub><pmid>28932556</pmid><doi>10.21037/jtd.2017.07.13</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| title | Expression of redox sensing factor Nrf2 in lung macrophages and type II pneumocytes as a prognostic factor in pneumothorax recurrence |
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