Biophysical characterisation of the novel zinc binding property in Suppressor of Fused

Suppressor of Fused (SUFU) is a highly conserved protein that acts as a negative regulator of the Hedgehog (HH) signalling pathway, a major determinant of cell differentiation and proliferation. Therefore, SUFU deletion in mammals has devastating effects on embryo development. SUFU is part of a mult...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.11139-10, Article 11139
Hauptverfasser:	Jabrani, Amira, Makamte, Staëlle, Moreau, Emilie, Gharbi, Yasmine, Plessis, Anne, Bruzzone, Lucia, Sanial, Matthieu, Biou, Valérie
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1141 631/57/2272/2273 82 82/80 82/83 Affinity Binding sites Cell differentiation Circular dichroism Clonal deletion Conserved sequence Crystal structure Hedgehog protein Histidine Humanities and Social Sciences Life Sciences multidisciplinary Repressors Science Science (multidisciplinary) Signal transduction Transcription factors Zinc
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