Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women
Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We anal...
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| description | Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the
Lachnospiraceae
family (Beta(SE) = 0.13(0.03), P = 8 × 10
−7
). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the
Lachnospiraceae
family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition. |
| doi_str_mv | 10.1038/s41598-017-10382-2 |
| format | Article |
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Lachnospiraceae
family (Beta(SE) = 0.13(0.03), P = 8 × 10
−7
). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the
Lachnospiraceae
family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-10382-2</identifier><identifier>PMID: 28894110</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/91 ; 631/326/2565/2134 ; 692/700/2814 ; 82/47 ; 82/58 ; Aged ; Aged, 80 and over ; Biodiversity ; Biomarkers ; Data processing ; Dietary fiber ; Dietary intake ; Dietary supplements ; Digestive system ; Docosahexaenoic Acids - metabolism ; Fatty acids ; Fatty Acids, Omega-3 - metabolism ; Fatty Acids, Omega-6 - metabolism ; Feces - microbiology ; Female ; Fish oils ; Food intake ; Gastrointestinal Microbiome ; Geriatrics ; Glutamates - biosynthesis ; Humanities and Social Sciences ; Humans ; Intestinal microflora ; Lachnospiraceae ; Metabolites ; Metabolome ; Metabolomics ; Metabolomics - methods ; Microbiota ; Middle age ; Middle Aged ; multidisciplinary ; Older people ; Omega-3 fatty acids ; Science ; Science (multidisciplinary) ; Serum levels</subject><ispartof>Scientific reports, 2017-09, Vol.7 (1), p.11079-11, Article 11079</ispartof><rights>The Author(s) 2017</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3892-d0e4b07ce38e733e5623604caefd15a9afa0da9e6173fd5236ad2d63e57657563</citedby><cites>FETCH-LOGICAL-c3892-d0e4b07ce38e733e5623604caefd15a9afa0da9e6173fd5236ad2d63e57657563</cites><orcidid>0000-0002-9315-9541 ; 0000-0002-9693-1859 ; 0000-0002-7891-6217 ; 0000-0002-7052-9546</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593975/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593975/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28894110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Menni, Cristina</creatorcontrib><creatorcontrib>Zierer, Jonas</creatorcontrib><creatorcontrib>Pallister, Tess</creatorcontrib><creatorcontrib>Jackson, Matthew A.</creatorcontrib><creatorcontrib>Long, Tao</creatorcontrib><creatorcontrib>Mohney, Robert P.</creatorcontrib><creatorcontrib>Steves, Claire J.</creatorcontrib><creatorcontrib>Spector, Tim D.</creatorcontrib><creatorcontrib>Valdes, Ana M.</creatorcontrib><title>Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the
Lachnospiraceae
family (Beta(SE) = 0.13(0.03), P = 8 × 10
−7
). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the
Lachnospiraceae
family. 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metabolism</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Fatty Acids, Omega-6 - metabolism</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Fish oils</topic><topic>Food intake</topic><topic>Gastrointestinal Microbiome</topic><topic>Geriatrics</topic><topic>Glutamates - biosynthesis</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Lachnospiraceae</topic><topic>Metabolites</topic><topic>Metabolome</topic><topic>Metabolomics</topic><topic>Metabolomics - methods</topic><topic>Microbiota</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Older people</topic><topic>Omega-3 fatty acids</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menni, Cristina</creatorcontrib><creatorcontrib>Zierer, Jonas</creatorcontrib><creatorcontrib>Pallister, Tess</creatorcontrib><creatorcontrib>Jackson, Matthew A.</creatorcontrib><creatorcontrib>Long, Tao</creatorcontrib><creatorcontrib>Mohney, Robert P.</creatorcontrib><creatorcontrib>Steves, Claire J.</creatorcontrib><creatorcontrib>Spector, Tim D.</creatorcontrib><creatorcontrib>Valdes, Ana M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menni, Cristina</au><au>Zierer, Jonas</au><au>Pallister, Tess</au><au>Jackson, Matthew A.</au><au>Long, Tao</au><au>Mohney, Robert P.</au><au>Steves, Claire J.</au><au>Spector, Tim D.</au><au>Valdes, Ana M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-09-11</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>11079</spage><epage>11</epage><pages>11079-11</pages><artnum>11079</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the
Lachnospiraceae
family (Beta(SE) = 0.13(0.03), P = 8 × 10
−7
). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the
Lachnospiraceae
family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28894110</pmid><doi>10.1038/s41598-017-10382-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9315-9541</orcidid><orcidid>https://orcid.org/0000-0002-9693-1859</orcidid><orcidid>https://orcid.org/0000-0002-7891-6217</orcidid><orcidid>https://orcid.org/0000-0002-7052-9546</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 45/91 631/326/2565/2134 692/700/2814 82/47 82/58 Aged Aged, 80 and over Biodiversity Biomarkers Data processing Dietary fiber Dietary intake Dietary supplements Digestive system Docosahexaenoic Acids - metabolism Fatty acids Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-6 - metabolism Feces - microbiology Female Fish oils Food intake Gastrointestinal Microbiome Geriatrics Glutamates - biosynthesis Humanities and Social Sciences Humans Intestinal microflora Lachnospiraceae Metabolites Metabolome Metabolomics Metabolomics - methods Microbiota Middle age Middle Aged multidisciplinary Older people Omega-3 fatty acids Science Science (multidisciplinary) Serum levels |
| title | Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women |
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