TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia
TREM2 plays a critical role in the alleviation of Alzheimer’s disease by promoting Aβ phagocytosis by microglia, but the detailed molecular mechanism underlying TREM2-induced direct phagocytic activity of Aβ remains to be revealed. We found that learning and memory functions were improved in aged TR...
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Veröffentlicht in: | Scientific reports 2017-09, Vol.7 (1), p.11118-12, Article 11118 |
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Sprache: | eng |
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