Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients
Reduced biodiversity and increased representation of opportunistic pathogens are typical features of gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients,...
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| Veröffentlicht in: | Scientific reports 2017-09, Vol.7 (1), p.11102-11, Article 11102 |
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| creator | Ticinesi, Andrea Milani, Christian Lauretani, Fulvio Nouvenne, Antonio Mancabelli, Leonardo Lugli, Gabriele Andrea Turroni, Francesca Duranti, Sabrina Mangifesta, Marta Viappiani, Alice Ferrario, Chiara Maggio, Marcello Ventura, Marco Meschi, Tiziana |
| description | Reduced biodiversity and increased representation of opportunistic pathogens are typical features of gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients, aged 83 ± 8. Microbiome biodiversity (Chao1 index) and relative abundance of individual bacterial taxa were determined by next-generation 16S rRNA microbial profiling. Their correlation with number of drugs, and indexes of multimorbidity and frailty were verified using multivariate linear regression models. The impact of gut microbiota biodiversity on mortality, rehospitalizations and incident sepsis was also assessed after a 2-year follow-up, using Cox regression analysis. We found a significant negative correlation between the number of drugs and Chao1 Index at multivariate analysis. The number of drugs was associated with the average relative abundance of 15 taxa. The drug classes exhibiting the strongest association with single taxa abundance were proton pump inhibitors, antidepressants and antipsychotics. Conversely, frailty and multimorbidity were not significantly associated with gut microbiota biodiversity. Very low Chao1 index was also a significant predictor of mortality, but not of rehospitalizations and sepsis, at follow-up. In aging, polypharmacy may thus represent a determinant of gut microbiota composition, with detrimental clinical consequences. |
| doi_str_mv | 10.1038/s41598-017-10734-y |
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Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients, aged 83 ± 8. Microbiome biodiversity (Chao1 index) and relative abundance of individual bacterial taxa were determined by next-generation 16S rRNA microbial profiling. Their correlation with number of drugs, and indexes of multimorbidity and frailty were verified using multivariate linear regression models. The impact of gut microbiota biodiversity on mortality, rehospitalizations and incident sepsis was also assessed after a 2-year follow-up, using Cox regression analysis. We found a significant negative correlation between the number of drugs and Chao1 Index at multivariate analysis. The number of drugs was associated with the average relative abundance of 15 taxa. The drug classes exhibiting the strongest association with single taxa abundance were proton pump inhibitors, antidepressants and antipsychotics. Conversely, frailty and multimorbidity were not significantly associated with gut microbiota biodiversity. Very low Chao1 index was also a significant predictor of mortality, but not of rehospitalizations and sepsis, at follow-up. In aging, polypharmacy may thus represent a determinant of gut microbiota composition, with detrimental clinical consequences.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-10734-y</identifier><identifier>PMID: 28894183</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/575 ; 692/700/1518 ; Abundance ; Aging ; Antidepressants ; Antipsychotics ; Biodiversity ; Fecal microflora ; Frailty ; Geriatrics ; Humanities and Social Sciences ; Intestinal microflora ; Mortality ; multidisciplinary ; Multivariate analysis ; Older people ; Opportunist infection ; Polypharmacy ; Proton pump inhibitors ; Regression analysis ; Relative abundance ; rRNA 16S ; Science ; Science (multidisciplinary) ; Sepsis</subject><ispartof>Scientific reports, 2017-09, Vol.7 (1), p.11102-11, Article 11102</ispartof><rights>The Author(s) 2017</rights><rights>2017. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-603e0cd54056033a1171f386e361a3cb4fd161646dc51cb087cf21eec69ae9d3</citedby><cites>FETCH-LOGICAL-c404t-603e0cd54056033a1171f386e361a3cb4fd161646dc51cb087cf21eec69ae9d3</cites><orcidid>0000-0001-9171-8592 ; 0000-0002-2680-2242 ; 0000-0002-5062-3164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593887/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593887/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28894183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ticinesi, Andrea</creatorcontrib><creatorcontrib>Milani, Christian</creatorcontrib><creatorcontrib>Lauretani, Fulvio</creatorcontrib><creatorcontrib>Nouvenne, Antonio</creatorcontrib><creatorcontrib>Mancabelli, Leonardo</creatorcontrib><creatorcontrib>Lugli, Gabriele Andrea</creatorcontrib><creatorcontrib>Turroni, Francesca</creatorcontrib><creatorcontrib>Duranti, Sabrina</creatorcontrib><creatorcontrib>Mangifesta, Marta</creatorcontrib><creatorcontrib>Viappiani, Alice</creatorcontrib><creatorcontrib>Ferrario, Chiara</creatorcontrib><creatorcontrib>Maggio, Marcello</creatorcontrib><creatorcontrib>Ventura, Marco</creatorcontrib><creatorcontrib>Meschi, Tiziana</creatorcontrib><title>Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Reduced biodiversity and increased representation of opportunistic pathogens are typical features of gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients, aged 83 ± 8. Microbiome biodiversity (Chao1 index) and relative abundance of individual bacterial taxa were determined by next-generation 16S rRNA microbial profiling. Their correlation with number of drugs, and indexes of multimorbidity and frailty were verified using multivariate linear regression models. The impact of gut microbiota biodiversity on mortality, rehospitalizations and incident sepsis was also assessed after a 2-year follow-up, using Cox regression analysis. We found a significant negative correlation between the number of drugs and Chao1 Index at multivariate analysis. The number of drugs was associated with the average relative abundance of 15 taxa. The drug classes exhibiting the strongest association with single taxa abundance were proton pump inhibitors, antidepressants and antipsychotics. Conversely, frailty and multimorbidity were not significantly associated with gut microbiota biodiversity. Very low Chao1 index was also a significant predictor of mortality, but not of rehospitalizations and sepsis, at follow-up. In aging, polypharmacy may thus represent a determinant of gut microbiota composition, with detrimental clinical consequences.</description><subject>692/308/575</subject><subject>692/700/1518</subject><subject>Abundance</subject><subject>Aging</subject><subject>Antidepressants</subject><subject>Antipsychotics</subject><subject>Biodiversity</subject><subject>Fecal microflora</subject><subject>Frailty</subject><subject>Geriatrics</subject><subject>Humanities and Social Sciences</subject><subject>Intestinal microflora</subject><subject>Mortality</subject><subject>multidisciplinary</subject><subject>Multivariate analysis</subject><subject>Older people</subject><subject>Opportunist infection</subject><subject>Polypharmacy</subject><subject>Proton pump inhibitors</subject><subject>Regression analysis</subject><subject>Relative abundance</subject><subject>rRNA 16S</subject><subject>Science</subject><subject>Science 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Tiziana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-09-11</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>11102</spage><epage>11</epage><pages>11102-11</pages><artnum>11102</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Reduced biodiversity and increased representation of opportunistic pathogens are typical features of gut microbiota composition in aging. Few studies have investigated their correlation with polypharmacy, multimorbidity and frailty. To assess it, we analyzed the fecal microbiota from 76 inpatients, aged 83 ± 8. Microbiome biodiversity (Chao1 index) and relative abundance of individual bacterial taxa were determined by next-generation 16S rRNA microbial profiling. Their correlation with number of drugs, and indexes of multimorbidity and frailty were verified using multivariate linear regression models. The impact of gut microbiota biodiversity on mortality, rehospitalizations and incident sepsis was also assessed after a 2-year follow-up, using Cox regression analysis. We found a significant negative correlation between the number of drugs and Chao1 Index at multivariate analysis. The number of drugs was associated with the average relative abundance of 15 taxa. The drug classes exhibiting the strongest association with single taxa abundance were proton pump inhibitors, antidepressants and antipsychotics. Conversely, frailty and multimorbidity were not significantly associated with gut microbiota biodiversity. Very low Chao1 index was also a significant predictor of mortality, but not of rehospitalizations and sepsis, at follow-up. In aging, polypharmacy may thus represent a determinant of gut microbiota composition, with detrimental clinical consequences.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28894183</pmid><doi>10.1038/s41598-017-10734-y</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9171-8592</orcidid><orcidid>https://orcid.org/0000-0002-2680-2242</orcidid><orcidid>https://orcid.org/0000-0002-5062-3164</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/575 692/700/1518 Abundance Aging Antidepressants Antipsychotics Biodiversity Fecal microflora Frailty Geriatrics Humanities and Social Sciences Intestinal microflora Mortality multidisciplinary Multivariate analysis Older people Opportunist infection Polypharmacy Proton pump inhibitors Regression analysis Relative abundance rRNA 16S Science Science (multidisciplinary) Sepsis |
| title | Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients |
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