Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice

Renal insufficiency is a frequent cancer-associated problem affecting more than half of all cancer patients at the time of diagnosis. To minimize nephrotoxic effects the dosage of anticancer drugs are reduced in these patients, leading to sub-optimal treatment efficacy. Despite the severity of this...

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Veröffentlicht in:	Oncoimmunology 2017-01, Vol.6 (8), p.e1320009
Hauptverfasser:	Cedervall, Jessica, Dragomir, Anca, Saupe, Falk, Zhang, Yanyu, Ärnlöv, Johan, Larsson, Erik, Dimberg, Anna, Larsson, Anders, Olsson, Anna-Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer DNase I GSK484 Health and Welfare Hälsa och välfärd kidney injury neutrophil extracellular traps Original Research Pathology Patologi
Online-Zugang:	Volltext
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