Ginsenoside Rg1 protects against neuronal degeneration induced by chronic dexamethasone treatment by inhibiting NLRP-1 inflammasomes in mice

Glucocorticoids (GCs) are known to alter neuronal plasticity, impair learning and memory and play important roles in the generation and progression of Alzheimer's disease. There are no effective drug options for preventing neuronal injury induced by chronic GC exposure. Ginsenoside Rg1 (Rg1) is...

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Veröffentlicht in:	International journal of molecular medicine 2017-10, Vol.40 (4), p.1134-1142
Hauptverfasser:	Zhang, Yaodong, Hu, Wen, Zhang, Biqiong, Yin, Yanyan, Zhang, Junyan, Huang, Dake, Huang, Rongrong, Li, Weiping, Li, Weizu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Alcohol Alzheimer's disease Animals Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Behavior Brain research CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - metabolism Caspases - genetics Caspases - metabolism Dementia Dexamethasone - administration & dosage Drug Administration Schedule Exploratory Behavior - drug effects Exploratory Behavior - physiology Frontal Lobe - drug effects Frontal Lobe - metabolism Frontal Lobe - pathology Gene Expression Regulation Ginsenosides - pharmacology Glucocorticoids - administration & dosage Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Inflammasomes - antagonists & inhibitors Inflammasomes - genetics Inflammasomes - metabolism Inflammation Interleukin-18 - genetics Interleukin-18 - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Laboratory animals Male Memory Mice Mice, Inbred ICR Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Motor Activity - drug effects Motor Activity - physiology Neurodegeneration Neurodegenerative Diseases - chemically induced Neurodegenerative Diseases - genetics Neurodegenerative Diseases - pathology Neurodegenerative Diseases - prevention & control Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology Signal Transduction Steroids Studies
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