The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination

Template switching during reverse transcription is crucial for retroviral replication. While strand transfer on the terminal repeated sequence R is essential to achieve reverse transcription, template switching from internal regions of the genome (copy choice) leads to genetic recombination. We have...

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Veröffentlicht in:	Nucleic acids research 2001-09, Vol.29 (18), p.3814-3821
Hauptverfasser:	Moumen, A, Polomack, L, Roques, B, Buc, H, Negroni, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Genome, Viral HIV-1 - genetics Human immunodeficiency virus 1 Humans Recombination, Genetic Repetitive Sequences, Nucleic Acid - genetics RNA, Viral - genetics Transcription, Genetic - genetics
Online-Zugang:	Volltext
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