CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium

The CD44 gene encodes several protein isoforms due to alternative splicing and post translational modifications. Given that CD44 variant isoform 9 (CD44v9) is expressed within Spasmolytic Polypeptide/TFF2‐Expressing Metaplasia (SPEM) glands during repair, CD44v9 may be play a funcitonal role during...

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Veröffentlicht in:	The Journal of pathology 2017-08, Vol.242 (4), p.463-475
Hauptverfasser:	Bertaux‐Skeirik, Nina, Wunderlich, Mark, Teal, Emma, Chakrabarti, Jayati, Biesiada, Jacek, Mahe, Maxime, Sundaram, Nambirajan, Gabre, Joel, Hawkins, Jennifer, Jian, Gao, Engevik, Amy C, Yang, Li, Wang, Jiang, Goldenring, James R, Qualls, Joseph E, Medvedovic, Mario, Helmrath, Michael A, Diwan, Tayyab, Mulloy, James C, Zavros, Yana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Adolescent Age Factors Aged Alternative splicing Animals CD44 antigen CD44‐deficient mice Cell lineage Cells, Cultured Epithelium Gastric Mucosa - pathology Gastric Mucosa - physiology gastric ulcer Genetic Variation - physiology Geriatrics Glands Histology Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Hyaluronan Receptors - physiology Isoforms Macrophages Macrophages - physiology Metaplasia Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Middle Aged Mucosa Older people Organoids Organoids - cytology Organoids - transplantation Protein Isoforms - genetics Protein Isoforms - metabolism Protein Isoforms - physiology Regeneration - genetics Regeneration - physiology repair Rodents Spasmolytic polypeptide Stomach Stomach Ulcer - genetics Stomach Ulcer - metabolism Stomach Ulcer - pathology Transplantation Ulcers Wound Healing - physiology Young Adult
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