Population Pharmacokinetic Model and Pharmacokinetic Target Attainment of Micafungin in Intensive Care Unit Patients

Objective To study the pharmacokinetics of micafungin in intensive care patients and assess pharmacokinetic (PK) target attainment for various dosing strategies. Methods Micafungin PK data from 20 intensive care unit patients were available. A population-PK model was developed. Various dosing regime...

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Veröffentlicht in:	Clinical pharmacokinetics 2017-10, Vol.56 (10), p.1197-1206
Hauptverfasser:	Martial, Lisa C., ter Heine, Rob, Schouten, Jeroen A., Hunfeld, Nicole G., van Leeuwen, Henk J., Verweij, Paul E., de Lange, Dylan W., Pickkers, Peter, Brüggemann, Roger J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antifungal agents Antifungal Agents - administration & dosage Antifungal Agents - pharmacokinetics Candida - drug effects Candida parapsilosis - drug effects Candidiasis - blood Candidiasis - drug therapy Cohort Studies Drug Delivery Systems - methods Drug dosages Echinocandins - administration & dosage Echinocandins - pharmacokinetics Female Humans Infections Intensive care Intensive Care Units - trends Internal Medicine Licenses Lipopeptides - administration & dosage Lipopeptides - pharmacokinetics Male Medicine Medicine & Public Health Micafungin Microbial Sensitivity Tests - methods Middle Aged Models, Biological Monte Carlo Method Original Original Research Article Pathogens Patients Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Prospective Studies Sepsis Simulation Young Adult
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