Transcription factors NRF2 and HSF1 have opposing functions in autophagy

Autophagy plays a critical role in the maintenance of cellular homeostasis by degrading proteins, lipids and organelles. Autophagy is activated in response to stress, but its regulation in the context of other stress response pathways, such as those mediated by heat shock factor 1 (HSF1) and nuclear...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.11023-12, Article 11023
Hauptverfasser:	Dayalan Naidu, Sharadha, Dikovskaya, Dina, Gaurilcikaite, Egle, Knatko, Elena V., Healy, Zachary R., Mohan, Hema, Koh, Glenn, Laurell, Axel, Ball, Graeme, Olagnier, David, de la Vega, Laureano, Ganley, Ian G., Talalay, Paul, Dinkova-Kostova, Albena T.
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/63 631/337/572/2102 631/92/609 96 96/95 Acetone Animals Autophagy Biodegradation Cell Line Cellular stress response Gene Expression Regulation Heat shock factors Heat Shock Transcription Factors - metabolism Homeostasis HSF1 protein Humanities and Social Sciences Humans Irradiation Lipids Mice multidisciplinary Neoplasms, Experimental - pathology NF-E2-Related Factor 2 - metabolism Organelles Osteoblasts - physiology Phagocytosis Science Science (multidisciplinary) Skin Neoplasms - pathology Squamous cell carcinoma Transcription factors Ultraviolet radiation
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