Heterogeneity of Stop Codon Readthrough in Single Bacterial Cells and Implications for Population Fitness

Gene expression noise (heterogeneity) leads to phenotypic diversity among isogenic individual cells. Our current understanding of gene expression noise is mostly limited to transcription, as separating translational noise from transcriptional noise has been challenging. It also remains unclear how t...

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Veröffentlicht in:	Molecular cell 2017-09, Vol.67 (5), p.826-836.e5
Hauptverfasser:	Fan, Yongqiang, Evans, Christopher R., Barber, Karl W., Banerjee, Kinshuk, Weiss, Kalyn J., Margolin, William, Igoshin, Oleg A., Rinehart, Jesse, Ling, Jiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	antibiotics bacteria Bacterial Proteins - biosynthesis Bacterial Proteins - genetics bet-hedging chloramphenicol Codon, Terminator Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Proteins - biosynthesis Escherichia coli Proteins - genetics gene expression Gene Expression Regulation, Bacterial Genes, Reporter Genetic Fitness Genotype Kinetics Luminescent Proteins - biosynthesis Luminescent Proteins - genetics mathematical models Microscopy, Fluorescence Models, Genetic One-Carbon Group Transferases Phenotype phenotypic variation protein synthesis Red Fluorescent Protein release factor ribosome RNA, Bacterial - biosynthesis RNA, Bacterial - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics stop codon transcription (genetics) Transcription, Genetic translational fidelity
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