Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia
Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other species different f...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2017-09, Vol.97 (3), p.782-788 |
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| creator | Faccini-Martínez, Álvaro A Ramírez-Hernández, Alejandro Barreto, Christian Forero-Becerra, Elkin Millán, Diego Valbuena, Elkin Sánchez-Alfonso, Andrea C Imbacuán-Pantoja, Wilson O Cortés-Vecino, Jesús A Polo-Terán, Luis J Yaya-Lancheros, Néstor Jácome, Jorge Palomar, Ana M Santibáñez, Sonia Portillo, Aránzazu Oteo, José A Hidalgo, Marylin |
| description | Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other
species different from
. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta. Sera specimens and ticks from animals as well as ticks from vegetation were studied for the presence of different
spp. Among 104 sera from patients with AUFS, 16.4%, 24.0%, and 2.9% patients seroconverted to dengue,
, and SFG
, respectively, with a case of probable coinfection or cross-reaction with
. None of the samples were reactive for
. Sera samples from 74 horses, 118 dogs, and 62 bovines were collected and showed 33.8%, 14.4%, and 50.0% of seroprevalence for SFG
, respectively. A total of 1,287 ixodid ticks were collected from animals/vegetation and processed in pools for polymerase chain reaction. Among them, 1.7% was positive for
genes, and
,
, and
spp. were found. These results confirm the circulation of dengue, different SFG
species and the relevance of other etiologies like leptospirosis and human anaplasmosis. Further studies must identify different epidemiological variables to establish proper surveillance and control programs. |
| doi_str_mv | 10.4269/ajtmh.16-0442 |
| format | Article |
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species different from
. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta. Sera specimens and ticks from animals as well as ticks from vegetation were studied for the presence of different
spp. Among 104 sera from patients with AUFS, 16.4%, 24.0%, and 2.9% patients seroconverted to dengue,
, and SFG
, respectively, with a case of probable coinfection or cross-reaction with
. None of the samples were reactive for
. Sera samples from 74 horses, 118 dogs, and 62 bovines were collected and showed 33.8%, 14.4%, and 50.0% of seroprevalence for SFG
, respectively. A total of 1,287 ixodid ticks were collected from animals/vegetation and processed in pools for polymerase chain reaction. Among them, 1.7% was positive for
genes, and
,
, and
spp. were found. These results confirm the circulation of dengue, different SFG
species and the relevance of other etiologies like leptospirosis and human anaplasmosis. Further studies must identify different epidemiological variables to establish proper surveillance and control programs.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.16-0442</identifier><identifier>PMID: 28722568</identifier><language>eng</language><publisher>United States: The American Society of Tropical Medicine and Hygiene</publisher><subject>Acute Disease ; Adolescent ; Adult ; Animals ; Child ; Colombia - epidemiology ; Female ; Humans ; Male ; Mammals ; Middle Aged ; Rickettsia - classification ; Rickettsia Infections - epidemiology ; Rickettsia Infections - microbiology ; Seroepidemiologic Studies ; Tick Infestations - epidemiology ; Tick Infestations - veterinary ; Ticks - microbiology ; Young Adult</subject><ispartof>The American journal of tropical medicine and hygiene, 2017-09, Vol.97 (3), p.782-788</ispartof><rights>The American Society of Tropical Medicine and Hygiene 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-9fa539f19af3b0c47ddc220e500dce8e48bb02e7778037371e65e36ec86854273</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590559/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590559/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28722568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faccini-Martínez, Álvaro A</creatorcontrib><creatorcontrib>Ramírez-Hernández, Alejandro</creatorcontrib><creatorcontrib>Barreto, Christian</creatorcontrib><creatorcontrib>Forero-Becerra, Elkin</creatorcontrib><creatorcontrib>Millán, Diego</creatorcontrib><creatorcontrib>Valbuena, Elkin</creatorcontrib><creatorcontrib>Sánchez-Alfonso, Andrea C</creatorcontrib><creatorcontrib>Imbacuán-Pantoja, Wilson O</creatorcontrib><creatorcontrib>Cortés-Vecino, Jesús A</creatorcontrib><creatorcontrib>Polo-Terán, Luis J</creatorcontrib><creatorcontrib>Yaya-Lancheros, Néstor</creatorcontrib><creatorcontrib>Jácome, Jorge</creatorcontrib><creatorcontrib>Palomar, Ana M</creatorcontrib><creatorcontrib>Santibáñez, Sonia</creatorcontrib><creatorcontrib>Portillo, Aránzazu</creatorcontrib><creatorcontrib>Oteo, José A</creatorcontrib><creatorcontrib>Hidalgo, Marylin</creatorcontrib><title>Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other
species different from
. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta. Sera specimens and ticks from animals as well as ticks from vegetation were studied for the presence of different
spp. Among 104 sera from patients with AUFS, 16.4%, 24.0%, and 2.9% patients seroconverted to dengue,
, and SFG
, respectively, with a case of probable coinfection or cross-reaction with
. None of the samples were reactive for
. Sera samples from 74 horses, 118 dogs, and 62 bovines were collected and showed 33.8%, 14.4%, and 50.0% of seroprevalence for SFG
, respectively. A total of 1,287 ixodid ticks were collected from animals/vegetation and processed in pools for polymerase chain reaction. Among them, 1.7% was positive for
genes, and
,
, and
spp. were found. These results confirm the circulation of dengue, different SFG
species and the relevance of other etiologies like leptospirosis and human anaplasmosis. Further studies must identify different epidemiological variables to establish proper surveillance and control programs.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Child</subject><subject>Colombia - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mammals</subject><subject>Middle Aged</subject><subject>Rickettsia - classification</subject><subject>Rickettsia Infections - epidemiology</subject><subject>Rickettsia Infections - microbiology</subject><subject>Seroepidemiologic Studies</subject><subject>Tick Infestations - epidemiology</subject><subject>Tick Infestations - veterinary</subject><subject>Ticks - microbiology</subject><subject>Young Adult</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1P3DAQhq2qVdlSjr1WPvZAtv5IbOdSCa3YBWmlSqVwtRxnspg6cbAdJP59sywgOIzmMO_HSA9C3yhZlkzUP81d7m-XVBSkLNkHtKClFAUVZfURLQghrKgFl0foS0p3hFDFKP2MjpiSjFVCLdD9-eha6F3wYfeIQ4evxpAztHgNDxDxJoZpxH-c_Qc5JxcSJGyGFp_ZKQO-HlrXdRBhyM4cTE10HvCl9wOkhN2Ab5z3kM0pXs0VfePMV_SpMz7ByfM-Rtfr87-ri2L7e3O5OtsWliuZi7ozFa87WpuON8SWsm0tYwQqQloLCkrVNISBlFIRLrmkICrgAqwSqiqZ5Mfo1yF3nJoeZs-Qo_F6jK438VEH4_T7y-Bu9S486KqqyTxzwI_ngBjuJ0hZ9y5Z8N4MEKakac0Ir7lSapYWB6mNIaUI3WsNJXqPST9h0lToPaZZ__3tb6_qFy78P0ZFkUg</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Faccini-Martínez, Álvaro A</creator><creator>Ramírez-Hernández, Alejandro</creator><creator>Barreto, Christian</creator><creator>Forero-Becerra, Elkin</creator><creator>Millán, Diego</creator><creator>Valbuena, Elkin</creator><creator>Sánchez-Alfonso, Andrea C</creator><creator>Imbacuán-Pantoja, Wilson O</creator><creator>Cortés-Vecino, Jesús A</creator><creator>Polo-Terán, Luis J</creator><creator>Yaya-Lancheros, Néstor</creator><creator>Jácome, Jorge</creator><creator>Palomar, Ana M</creator><creator>Santibáñez, Sonia</creator><creator>Portillo, Aránzazu</creator><creator>Oteo, José A</creator><creator>Hidalgo, Marylin</creator><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201709</creationdate><title>Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia</title><author>Faccini-Martínez, Álvaro A ; 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Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other
species different from
. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta. Sera specimens and ticks from animals as well as ticks from vegetation were studied for the presence of different
spp. Among 104 sera from patients with AUFS, 16.4%, 24.0%, and 2.9% patients seroconverted to dengue,
, and SFG
, respectively, with a case of probable coinfection or cross-reaction with
. None of the samples were reactive for
. Sera samples from 74 horses, 118 dogs, and 62 bovines were collected and showed 33.8%, 14.4%, and 50.0% of seroprevalence for SFG
, respectively. A total of 1,287 ixodid ticks were collected from animals/vegetation and processed in pools for polymerase chain reaction. Among them, 1.7% was positive for
genes, and
,
, and
spp. were found. These results confirm the circulation of dengue, different SFG
species and the relevance of other etiologies like leptospirosis and human anaplasmosis. Further studies must identify different epidemiological variables to establish proper surveillance and control programs.</abstract><cop>United States</cop><pub>The American Society of Tropical Medicine and Hygiene</pub><pmid>28722568</pmid><doi>10.4269/ajtmh.16-0442</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute Disease Adolescent Adult Animals Child Colombia - epidemiology Female Humans Male Mammals Middle Aged Rickettsia - classification Rickettsia Infections - epidemiology Rickettsia Infections - microbiology Seroepidemiologic Studies Tick Infestations - epidemiology Tick Infestations - veterinary Ticks - microbiology Young Adult |
| title | Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia |
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