Overexpression of REIC/Dkk-3 suppresses the expression of CD147 and inhibits the proliferation of human bladder cancer cells

Our group previously developed an adenoviral vector encoding the REIC/Dkk-3 gene (Ad-REIC), a tumor suppressor, for cancer gene therapy. The Ad-REIC agent induces apoptosis and inhibits invasion in a number of cancer cell lines; however, the molecular mechanisms underlying its effects remain unclear...

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Veröffentlicht in:	Oncology letters 2017-09, Vol.14 (3), p.3223-3228
Hauptverfasser:	Horikawa, Yuhei, Watanabe, Masami, Sadahira, Takuya, Ariyoshi, Yuichi, Kobayashi, Yasuyuki, Araki, Motoo, Wada, Koichiro, Ochiai, Kazuhiko, Li, Shun-Ai, Nasu, Yasutomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Apoptosis Binding sites Bladder cancer Cancer therapies Care and treatment CD147 cell proliferation Development and progression EMMPRIN Gene expression Gene therapy Genetic aspects Health aspects Kinases Laboratories Metastasis Oncology Phosphorylation Plasmids Prostate cancer Proteins REIC/Dkk-3 Skin cancer Studies Tumor suppressor genes Tumors
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