α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis

Neuroinflammation in utero may result in life-long neurological disabilities. Microglia play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia. We hypothesized that agonism on α7 nicotinic acetylc...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.10645-15, Article 10645
Hauptverfasser:	Cortes, M., Cao, M., Liu, H. L., Moore, C. S., Durosier, L. D., Burns, P., Fecteau, G., Desrochers, A., Barreiro, L. B., Antel, J. P., Frasch, M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 38/77 38/91 631/136/1425 631/378/2571/219 631/378/340 631/378/371 alpha7 Nicotinic Acetylcholine Receptor - agonists alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors alpha7 Nicotinic Acetylcholine Receptor - metabolism Animals Biomarkers Brain - metabolism Brain - pathology Cells, Cultured Computational Biology - methods Cytokines - metabolism Fetus Fetuses Gene expression Gene Expression Profiling Gene Ontology Genotype & phenotype Homeostasis Humanities and Social Sciences Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Iron Iron - metabolism Lipopolysaccharides Microglia Microglia - drug effects Microglia - metabolism multidisciplinary Neonates Neurodevelopment Neuroprotection Reproducibility of Results Science Science (multidisciplinary) Sheep Signal transduction Signal Transduction - drug effects Transcriptome
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