N-myc regulates growth and fiber cell differentiation in lens development

Myc proto-oncogenes regulate diverse cellular processes during development, but their roles during morphogenesis of specific tissues are not fully understood. We found that c-myc regulates cell proliferation in mouse lens development and previous genome-wide studies suggested functional roles for N-...

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Veröffentlicht in:	Developmental biology 2017-09, Vol.429 (1), p.105-117
Hauptverfasser:	Cavalheiro, Gabriel R., Matos-Rodrigues, Gabriel E., Zhao, Yilin, Gomes, Anielle L., Anand, Deepti, Predes, Danilo, de Lima, Silmara, Abreu, Jose G., Zheng, Deyou, Lachke, Salil A., Cvekl, Ales, Martins, Rodrigo A.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell cycle cell differentiation Cell Differentiation - genetics Cell Nucleus - metabolism cell proliferation Cell Proliferation - genetics Cell Survival - genetics Denucleation DNA Embryonic Development - genetics Eye eyes fiber cells gene expression regulation Gene Expression Regulation, Developmental gene regulatory networks Lens, Crystalline - cytology Lens, Crystalline - growth & development Lens, Crystalline - metabolism Mice morphogenesis N-Myc Proto-Oncogene Protein - metabolism Oncogene Organogenesis Proto-Oncogene Proteins c-myc - metabolism proto-oncogenes stem cells transcription (genetics) Transcription factor transcription factors Transcription, Genetic Transcriptome - genetics
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