Towards quantitative analysis of gene regulation by enhancers

Enhancers are regulatory DNA sequences that can activate transcription over large distances. Recent studies have revealed the widespread role of distant activation in eukaryotic gene regulation and in the development of various human diseases, including cancer. Here we review recent progress in the...

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Veröffentlicht in:	Epigenomics 2017-09, Vol.9 (9), p.1219-1231
Hauptverfasser:	Nizovtseva, Ekaterina V, Todolli, Stefjord, Olson, Wilma K, Studitsky, Vasily M
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Animals Binding sites Bioinformatics Chromatin Chromatin - genetics Chromatin - metabolism Communication Computer applications Deoxyribonucleic acid distant action DNA Enhancer Elements, Genetic Enhancers Epigenesis, Genetic Gene expression Gene regulation Gene sequencing Genomes Genomics - methods Humans mechanisms Nucleotide sequence promoters Proteins Quantitative analysis Review RNA polymerase Transcription Transcription factors Yeast
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